adipoq gene and diabetes - Adiponectin is encoded by the gene diabetes mellitus world day ADIPOQ located in the chromosomal region 3q27ADIPOQ spans 16 kb and contains three exons Previous genomewide linkage scans have identified 3q27 as a susceptibility locus for diabetes 23Various single nucleotide polymorphisms SNPs in ADIPOQ have been reported to be associated with adiponectin levels andor diabetes but with inconsistent results Association of ADIPOQ gene variants with body weight type 2 diabetes Adiponectin is also referred to as ACRP30 AdipoQ apM1 or GBP28 Takahashi M Matsuda M et al Association of adiponectin mutation with type 2 diabetes A candidate gene for the insulin resistance syndrome Diabetes 20025123258 doi 102337diabetes5172325 Google Scholar 78 Spranger J Kroke A Mohlig M Bergmann MM Ristow Adiponectin also known as Acrp30 AdipoQ GBP28 and apM1 is a 244amino acid protein secreted mainly by the adipose tissue It was This human chromosome 3q27 has been identified as a region carrying a susceptibility gene for type 2 diabetes and metabolic syndrome 2021 Adiponectin A Promising Target for the Treatment of Diabetes and Its Adiponectin gene polymorphisms associated with diabetes mellitus A Common Variants in the Adiponectin Gene American Diabetes Association The adiponectin a 30kDa protein is encoded by the gene APM1ADIPOQ consisting of three exons and two introns located on chromosome 3q27 where a locus of diabetes susceptibility was mapped Until now 19 common polymorphisms of 14 known candidate genes have been analyzed around the world for their contribution to the prevalence and incidence Adiponectin Role in Physiology and Pathophysiology PMC ADIPOQ adiponectin affects fatty acid oxidation glucose uptake and glycogenesis all of which are involved in the development of diabetes As a result ADIPOQ is being studied as a potential gene for type 2 diabetes mellitus T2DM which is a polygenic disease with genetic inheritance what test is used to diagnose gestational diabetes Adiponectin a Therapeutic Target for Obesity Diabetes and There is an association between ADIPOQ polymorphisms and type 2 diabetes mellitus Adiponectin affects insulin sensitivity in diabetic patients through the following direct and indirect mechanisms These cytokines decrease the expression of the ADIPOQ gene and ultimately inhibit the synthesis and secretion of adiponectin but omega3 Effect of Genetic Variations in the ADIPOQ Gene on Susceptibility to Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies Increased adiponectin levels have been shown to be associated with a lower risk of type 2 diabetes To understand the relations between genetic variation at the adiponectinencoding gene ADIPOQ and adiponectin levels and subsequently its role in disease we conducted a deep resequencing experiment of ADIPOQ in 14002 subjects including 12514 Europeans 594 African Americans and 567 Background Adiponectin secreted mainly by mature adipocytes is a protein with insulinsensitising and antiatherogenic effects Human adiponectin is encoded by the ADIPOQ gene on the chromosomal locus 3q27 Variations in ADIPOQ are associated with obesity type 2 diabetes T2DM and related phenotypes in several populations Our aim was to study the association of the ADIPOQ variations with Adiponectin Structure Physiological Functions Role in Diseases and The adiponectin gene situated on chromosome 3q27 corresponds to a susceptibility locus for diabetes Various crosssectional studies have demonstrated an association between singlenucleotide polymorphisms SNPs within the adiponectin gene ADIPOQ and diabetes Adiponectin gene polymorphisms and risk of type 2 diabetes an updated The ADIPOQ adiponectincoding gene which is located in chromosome 3q27 proposed as a genomic locus for the T2D using genomewide scans 7 8 The association of two common single nucleotide polymorphisms SNPs of ADIPOQ gene rs266729 and rs1501299 with risk of T2D have been investigated in different populations buah obat diabetes alami worldwide 10 11 Given
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