advance diabetes study results - Effects of blood pressure lowering and cardiomyopathy and diabetes intensive glucose control intervention on renal events in the ADVANCE Study Figure modified from Ref 7 Efficacy and safety of routine blood pressure lowering in older patients with diabetes results from the ADVANCE trial J Hypertens 20102811411149 A Summary of the ADVANCE Trial Diabetes Care Results from randomized controlled trials have demonstrated conclusively that the risk of microvascular complications can be reduced by intensive glycemic control in patients with type 1 12 and type 2 diabetes 35In the Diabetes Control and Complications Trial DCCT there was an 60 reduction in development or progression of diabetic retinopathy nephropathy and neuropathy Shichiri M Kishikawa H Ohkubo Y Wake N Longterm results of the Kumamoto Study on optimal diabetes control in type 2 diabetes patients Diabetes Care 200023Suppl 2B21B29 PubMed METHODS ADVANCE was an international randomized trial that tested the effects of intensive glucose and blood pressure control strategies on microvascular and macrovascular outcomes in 11140 patients with type 2 diabetes 1314 For the present study we obtained stored specimens from 7283 participants for measurements of 15AG hscTnT and NTproBNP 3 Samples from trial centers in India The ADVANCE trial new findings and updated results Results From a Randomized Trial of Intensive Glucose Management Using Glycemic excursions and subclinical cardiac damage in adults with type The publication of the UK Prospective Diabetes Study UKPDS in 1998 helped to shape the management of type 2 diabetes in recent years 1 The study dem has no significant effect in reducing macrovascular disease The results of ADVANCE do not exclude best time to take diabetes medicine a minor effect on cardiovascular disease indeed cardiovascular mortality was reduced UK Prospective Diabetes Study UKPDS Group Mortality results Diabetes 197019Suppl789830 Study rationale and design of ADVANCE action in diabetes and vascular disease preterax For the 110 participants included in the primary analysis mean SD age was 61 12 years and mean HbA 1c was 89 23 738 16 mmolmol During the study CGMmeasured mean glucose was 170 mgdL for the intensive group n 60 vs 175 mgdL for the standard group n 50 riskadjusted difference 7 mgdL 95 CI 19 to 5 P 025Only 7 of the intensive group achieved the Intensive Blood Glucose Control and Vascular Outcomes in Patients with Rationale and design of the ADVANCE study a randomised trial of blood pressure lowering and intensive glucose control in highrisk individuals with type 2 diabetes mellitus Action in Diabetes and Vascular Disease PreterAx and DiamicroN ModifiedRelease Controlled Evaluation J Hypertens Suppl 200119S2128 13 ACCORD news conference 14 The ADVANCE Trial results clinical implications and perspectives 10Year Followup of Intensive Glucose Control in Type 2 Diabetes Followup of BloodPressure Lowering and Glucose Control in Type 2 Diabetes Effects of Intensive Glucose Lowering in Type 2 Diabetes What did the ACCORD ADVANCE and VA Diabetes trials show The United Kingdom Prospective Diabetes Study UKPDS a randomized prospective multicenter trial showed that intensive glucose therapy in patients with newly diagnosed type 2 diabetes mellitus The Action in Diabetes and Vascular Disease Preterax and Diamicron Modified Release Controlled Evaluation ADVANCE trial assessed the effects of routine bahaya covid bagi penderita diabetes bloodpressure lowering and intensive
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