adverse effect dexamethasone induced diabetes infection mice rat animal - Body weights BWs and food consumption daftar pustaka tandra 2008 diabetes A Male and B female WT or Nrf2KO mice body weights plotted against time during 13 weeks of treatment with dexamethasone p 005 for dexamethasonetreated mice of both genotypes versus vehicletreated mice from week 5 and week 8 of treatment onwards p 005 of Nrf2KO dexamethasonetreated mice versus vehicletreated Dexamethasone Administration in Mice Leads to Less Body Weight Gain Metabolomics Based Profiling of Dexamethasone Side Effects in Rats All these effects of dexamethasone were similar between male and female mice as well as between WT and Nrf2KO mice Hepatic NRF2 signaling and gluconeogenic gene expression were not affected by dexamethasone A 2day dexamethasone treatment was also sufficient to increase insulin levels without affecting body weight and glucose levels In a recent comprehensive metabolomic study based on a single dose exposure to Dex in healthy human volunteers multiple metabolic changes predicted the side effects related to this exposure Bordag et al 2015 However this prediction could not be validated without observing the actual side effects which only can be done in an animal model The Effects of Probiotic Bacillus Spores on DexamethasoneTreated Rats Metabolomics Based Profiling of Dexamethasone Side Effects in Rats Hypertension and diabetes are common side effects of glucocorticoid treatment To determine whether peroxisome proliferatoractivated receptorα PPARα mediates these sequelae mice Fat feeding potentiates the diabetogenic effect of dexamethasone in SingleDose Dexamethasone Induces WholeBody Insulin Resistance and Effect of Dexamethasone on Glucose Tolerance and Fat Metabolism in a Dexamethasone Dex is a synthetic glucocorticoid that has antiinflammatory and immunosuppressant effects and is used in several conditions such as asthma and severe allergy Patients receiving Dex either at a high dose or for daftar pustaka konsensus diabetes melitus tipe 1 a long time might develop several side effects such as hyperglycemia Dexamethasone induction of hypertension and diabetes is PPARα Dexamethasone Administration in Mice Leads to Less Body Weight Gain The differences observed between the effects of acute dexamethasone treatment on the rat and DIO mouse insulin resistance models may be attributable to the diets provided to the animals In the present study mice were dosed with dexamethasone after being placed on a highfat diet for 8 wk whereas in the previous study rats were kept on a Psammomys obesus the desert rat is a welldefined animal model for dietary induced insulin resistance and type 2 diabetes Seasonal variation cortisol has been reported in these rats 95 but no such seasonal variations were reported in the nonseasonal Wistar rat in which the ordinary diet will not induce diabetes 77 STZinduced diabetic rats were injected with a rapidacting insulin 8 units IN 4 days after diabetes induction the rats killed 180 min later and heparinreleasable LPL activity determined in perfused hearts inset Heparinreleasable LPL activity was also determined before and after termination of the 3h euglycemichyperinsulinemic clamp Dexamethasone and Diabetes Real or Imagined Risk The effect of MET on the nonsignificant alteration of triglycerides serum levels in the DEXA MET group is in accordance with a systematic review that evaluated the effect of MET versus other antidiabetic drugs regarding lipid metabolism in patients with type 2 diabetes showing that the decrease of the triglycerides induced by MET depends on Dexamethasone and Diabetes Real or Imagined Risk Dexamethasone and Diabetes Real or Imagined Risk Anesth Analg 2024 Sep 11393478 doi 101213ANE0000000000007151 Dexamethasone adverse effects Dexamethasone therapeutic use diabetes insipidus diagnostika Diabetes Mellitus drug therapy
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