alfacalcidol and diabetes nephropathy xu 2010 - Dialysate calcium alfacalcidol and clinical outcomes autoreactive tcells in type 1 diabetes A Effects of 1αCalcidol Alfacalcidol on Microvascular Effects of alfacalcidol on cardiovascular outcomes according Clinical practice recommendations for treatment with active Effects of 1αCalcidol Alfacalcidol on Microvascular Endothelial Function Arterial Stiffness and Blood Pressure in Type II Diabetic Nephropathy Patients Get access to the full version of this article Administration of alfacalcidol for patients with predialysis Alfacalcidol significantly improved CSBP with trends of improvement in arterial stiffness and peripheral BP Alfacalcidol appears to be more beneficial in vitamin Ddeficient patients Citing Literature Comparison of oral and intravenous Alfacalcidol in chronic Relationship of serum calcium concentration with chronic Vitamin D protects against diabetic nephropathy Evidence Role of Vitamin D and Its Analogues in Diabetic Nephropathy In patients with chronic kidney disease CKD renal synthesis of active vitamin D 125dihydroxyvitamin D 125 OH 2 D declines with kidney function loss Low serum 125 OH 2 D concentrations contribute to hypocalcaemia secondary hyperparathyroidism and the spectrum of CKDmineral and bone disorder MBD 1 Our results demonstrated that thriceweekly oral alfacalcidol administration is more effective than an equivalent thriceweekly IV regimen We also found that oral administration of alfacalcidol was associated with a significant increase of serum calcium levels a lower serum PTH and total alkaline phosphatase levels Effects of 1αCalcidol Alfacalcidol on Microvascular Vitamin D its analogues in type 2 diabetic nephropathy a Vitamin D3treated patients with diabetic nephropathy had a statistically significant reduction in 24hour proteinuria weighted mean difference 044 95 CI 054 to 034 Z 880 P Effects of 1αCalcidol Alfacalcidol on Microvascular PDF The Association between Alfacalcidol 1alpha The six studies included in this review evaluating the role of vitamin D or its analogues in type 2 diabetic nephropathy have large variations in their study designs Vitamin D analogues showed significant beneficial effects on kidney functions This post hoc analysis showed that the effects of alfacalcidol on cardiovascular outcomes were not significantly modified by DCa Introduction The hemodialysis HD regimen for kidney failure remained experiencebased Does alfacalcidol reduce cardiovascular complications in Our metaanalysis was specifically designed to include patients with diabetic nephropathy and our results demonstrated that VD supplementation including calcitriol alfacalcidol and vitamin D3 could reduce urinary protein excretion Effects of Vitamin D Supplementation on Renal Function Objectives This study aims to explore the relationship of serum calcium Ca concentration with diabetic kidney disease DKD and allcause mortality among type 2 diabetes mellitus T2DM patients using National Health and Nutrition Examination Surveys NHANES Methods Data of T2DM patients aged 40 years were screened from the NHANES database from 1999 to 2018 The outcomes were the risk Research currently is underway to establish if manfaat teripang untuk diabetes there is a link between the effect of 1alpha OH D3 and Type II Diabetic Nephropathy patients and whether the Type II regulated diabetic Efficacy and safety of vitamin D3 in patients with diabetic Abstract ImportancePatients with chronic kidney disease have impaired vitamin D activation and elevated cardiovascular risk Observational studies in patients treated with hemodialysis showed that the use of active vitamin D sterols was associated with lower risk of allcause mortality regardless of parathyroid hormone levels Vitamin D and Diabetic Kidney Disease PMC Vitamin D deficiency has been reported to be associated with the development of type 1 and type 2 DM and diabetic nephropathy 7 Recent clinical and experimental data have highlighted a potential renoprotective effect of vitamin D and its analogs independent of their action on calcium and phosphorus metabolism 8 9 10 The mechanism by which vi Effect of Oral Alfacalcidol on Clinical Outcomes in Patients The Emerging Role of Vitamin D and Vitamin D Receptor in In 2010 a largescale randomized controlled study VITAL showed that both type 2 diabetes and DN patients treated with 2 μg paricalcitol for 24 weeks got a reduction of residual albuminuria excretion Across the entire treatment phase the UACR has also been decreased significantly and reached its peak of 28 in the 12th week Throughout the followup period the association between CVD events and alfacalcidol use was detected when adjusted for age sex diabetes hypertension use of reninangiotensin system inhibitors estimated glomerular filtration rate and albumin and parathyroid hormone Individuals were randomized 11 to a starting dose of 05 μg of oral alfacalcidol daily vs usual care using stratified blocks for age sex diabetic nephropathy cardiovascular disease and dialysis vintage Alfacalcidol significantly improved CSBP with trends of improvement in arterial stiffness and peripheral BP Alfacalcidol appears to be more beneficial in vitamin Ddeficient patients Keywords alfacalcidol arterial stiffness diabetic nephropathy high sensitivity Creactive protein microvascular endothelial function Because the cardiovascular effect of alfacalcidol could be modulated by bone turnover status this posthoc analysis of the JDAVID examined how alkaline phosphatase ALP a more precise marker of bone turnover than parathyroid hormone PTH modifies the impact of alfacalcidol In a 56 nephrectomized rat model paricalcitol a synthetic analog of vitamin D was found to reduce glomerular and tubulointerstitial damage hypertension and proteinuria possibly by dampening the renal RAS activation Freundlich et al 2008 Diabetic kidney disease DKD is a leading cause of endstage kidney disease worldwide There are numerous studies supporting vitamin D as a renoprotector potentially delaying the onset of DKD This review summarizes the findings of current research on vitamin D and apa penyakit diabetes its role in DKD
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