alloxan induced diabetes mechanisms and effects - Diabetes trials of alloxan monohydrate have obat diabetes gula basah been one of the most used diabetes chemicals The action mechanism in β cells has been thoroughly studied and understood quite well Experimental diabetes induced by alloxan and streptozotocin The Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter In the presence of intracellular thiols especially glutathione alloxan generates reactive oxygen species ROS in a cyclic redox reaction with its reduction product dialuric acid Autoxidation of dialuric acid generates superoxide radicals Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals 78 79It has been successfully induced in a variety of animal species rabbits mice rats monkeys cats and dogs 80 81Alloxan has been administered in single or multiple doses through different routes intraperitoneal intravenous and Alloxan is a cyclicurea derivative which is a highly effective diabetogenic agent used widely as a tool to induce experimental diabetes Diabetes follows the alloxaninduced destruction of the pancreatic islet beta cell and in the appropriate dose it is selective to islet beta cell producing minimal effects on other structures Cooperstein The mechanism of action of alloxan in order to induce diabetes mellitus in experimental animals is highlighted and it is found to be selectively toxic to pancreatic beta cells Diabetes mellitus is a metabolic disorder constituting a major health concern today whose prevalence has continuously increased worldwide over the past few decades Moreover it has been considered as an incurable The mechanisms of alloxan obat luka diabetes basah harga salep metcovazin di apotik and streptozotocininduced diabetes Pdf Alloxan Monohydrate Induced Diabetes a Comprehensive Review These hydroxyl radicals are ultimately responsible for the death of the beta cells which have a particularly low antioxidative defence capacity and the ensuing state of insulindependent alloxan diabetes As a thiol reagent alloxan also selectively inhibits glucoseinduced insulin secretion through its ability to inhibit the beta cell Alloxan mechanism of action Alloxan has two distinct pathological effects it selectively inhibits glucoseinduced insulin secretion through specific inhibition of glucokinase the glucose sensor of Fig 1 Phasic blood glucose response to a diabetogenic dose of alloxan tetraphasic IIV or streptozotocin triphasic the first phase Alloxan Induced Diabetes Mechanisms and Effects ResearchGate Alloxan Induced Diabetes Mechanisms and Effects Alloxaninduced diabetes a common model for evaluating the glycemic Notably alloxan is far less expensive and more readily available than streptozotocin On this ground one will logically expect a preference for use of alloxan in experimental diabetes studies AlloxanInduced Diabetes Mellitus an overview ScienceDirect One of the possible explanations for this alloxaninduced metabolic effect is probably connected to alloxaninduced increase in intracellular calcium Namely alloxan is able to depolarize B cells which can lead to opening of voltage dependent calcium channels and increase in cytosolic calcium level Dean Matthews 1972 PDF The mechanisms of alloxan and streptozotocininduced diabetes Springer The mechanisms of alloxan and streptozotocininduced diabetes Springer Download Citation Alloxan Induced Diabetes Mechanisms and Effects Diabetes mellitus is a metabolic disorder constituting a major health concern today whose prevalence has continuously PDF Alloxaninduced diabetes a common pengertian dari diabetes melitus model for evaluating the
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