alloxan monohydrate dose to induced diabetes in rats - A single intraperitoneal injection of freshly swelling in ankles diabetes prepared alloxan monohydrate 150mgkg bw and at a concentration of 20mgml was used to induced diabetes in overnight fasted rats 12 After 3 days Induction of Diabetes Mellitus Using Alloxan in Sprague Dawley Rats Alloxan An unpredictable drug for diabetes induction PMC Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals 78 79It has been successfully induced in a variety of animal species rabbits mice rats monkeys cats and dogs 80 81Alloxan has been administered in single or multiple doses through different routes intraperitoneal intravenous and A New model for Alloxaninduced diabetes mellitus in rats ResearchGate In this study when diabetes was induced with alloxan approximately 80 of the rats showed diabetes induction within 12 days Treatment with NPH and glargine insulin at a dose of 150 mgkg of alloxaninduced diabetes required less insulin administration than 200 mgkg of alloxan Rat model of foodinduced nonobesetype 2 diabetes mellitus Alloxaninduced diabetes a common model for evaluating the glycemic Diabetes was induced using intravenous alloxan Sigma Co USA at a dose of 42 mgkg of body weight into tail veins Only animals with clinical signs of severe diabetes and fasting glucose 250 mgdL in two successive determinations 1 and 2 weeks after diabetes induction were used Streblus asper attenuates alloxaninduced diabetes in rats and Purpose The use of rodent models for diabetes particularly with pancreatic islet transplantation has been prevalent in various preclinical trials The purpose of this study is to establish a diabetes diabetes cardio journal mellitus DM model in Sprague Dawley SD rats using alloxan evaluated by assessing alloxan dosage the induction rate of diabetes and glucose stability through insulin treatment Induction of Diabetes Mellitus Using Alloxan in Sprague Dawley Rats Alloxan monohydrate was dissolved in normal saline and a freshly prepared solution was administrated orally to animals at a dose of 100 mgkg bw Animals were allowed free access to food and water 30 min after injection and after 72 h the blood glucose of the rats was measured again The dose requirement for alloxan differs to cause diabetes varies on choice of animal species and route of administration Nutritional status of animals also plays a great role in creation of In this rat model diabetes mellitus was chemically induced with alloxan monohydrate which destroys the insulinproducing ꞵcells of the pancreas to induce persistent diabetic hyperglycemia AlloxanInduced Diabetes Causes Morphological and Ultrastructural Alloxan induced a dosedependent mortality in 25 3333 and 40 of rats receiving 150 mgkg 160 mgkg and 170 mg kg of alloxan within 15 days of injection respectively In rabbits a very high mortality of about 80 was seen with rapid iv injection of alloxan compared to 30 with slow iv injection Alloxan Induced Diabetes Mechanisms and Effects ResearchGate The degeneration observed in the pancreas of alloxaninduced diabetic rats is due to the necrotic action of alloxan monohydrate on the β cells Earlier work by Bansal 2002 26 reported specific necrosis of the pancreatic islets after exposure of the islet to alloxan Pdf Alloxan Monohydrate Induced anemia y diabetes Diabetes a Comprehensive Review
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