alpha amylase enzyme in diabetes mellitus - AlphaAmylase and AlphaGlucosidase Enzyme Inhibition and diabetes melitus enzim jantung Antioxidant Potential of 3Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia Type 2 diabetes mellitus T2DM is characterized by elevated blood glucose levels and can lead to serious complications such as nephropathy neuropathy The alpha αamylase is a calcium metalloenzyme that aids digestion by breaking down polysaccharide molecules into smaller ones such as glucose and maltose In addition the enzyme causes postprandial hyperglycaemia and blood glucose levels to rise αAmylase is a wellknown therapeutic target for Results To overcome the research gap the alphaamylase enzyme is regarded as a good target for antidiabetic agents to design the drug and provide an alternate approach for the treatment of type 2 diabetes mellitus Basically alphaamylase inhibitors are classified into two groups proteinaceous inhibitors and nonproteinaceous inhibitors Alphaamylase as molecular target for treatment of diabetes mellitus A Inhibition mechanism of alphaamylase a diabetes target by a Inhibition of Key Enzymes Linked to Type 2 Diabetes and Sodium AlphaAmylase and AlphaGlucosidase Enzyme Inhibition and Antioxidant Diabetes mellitus is a chronic metabolic disease the most common form of which is type II diabetes mellitus which accounts for about 9095 of all cases 15 αamylase breaks down αAmylase Inhibitors Performance in the Control of Diabetes Mellitus AlphaAmylase as Molecular Target for Treatment of Diabetes Mellitus A In vitro and in vivo αamylase and αglucosidase inhibiting activities Diabetes mellitus DM a metabolic disease syndrome is ranked among the persistent and most challenging public health burdens worldwide The enzyme alphaamylase 14αDglucan glucanohydrolase EC 3211 is a key therapeutic target that has diabetes melitus gender been exploited for developing several synthetic drugs such as acarbose voglibose and An Insight of Alphaamylase Inhibitors as a Valuable Tool in the Natural products as alphaamylase and alphaglucosidase inhibitors and Alphaamylase inhibition can treat diabetes mellitus ResearchGate This review mainly focused on alpha α amylase as potential biological target for treatment of Diabetes mellitus and summarized all the reported derivatives of different nucleus like Background αamylase and αglucosidase digest the carbohydrates and increase the postprandial glucose level in diabetic patients Inhibiting the activity of these two enzymes can control postprandial hyperglycemia and reduce the risk of developing diabetes Bitter gourd or balsam pear is one of the important medicinal plants used for controlling postprandial hyperglycemia in diabetes The lowering of postprandial hyperglycemia through the inhibition of keyenzymes linked to type 2 diabetes mellitus αamylase and αglucosidase is a critical therapeutic strategy used to controlmanage type 2 diabetes αGlucosidase after catalyzing the hydrolysis of α 1 4glycosidic bonds to release glucose into the blood stream The inhibition of alphaglucosidase and alphaamylase enzymes involved in the digestion of carbohydrates can significantly reduce the postprandial increase of blood glucose and therefore can be an important strategy in the management of blood glucose level in type 2 diabetic and borderline patien Diabetes mellitus is the most widespread disorders prevalent in current period αAmylase enzyme plays a key role in the onset of the abnormal condition by breaking starch into glucose hence its inhibitors need to be studied thoroughly 2000 Subsite mapping of the human pancreatic alphaamylase active diabetes cause hair loss site through structural kinetic
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