animal models in type 2 diabetes research an overview - Animal models in type 2 diabetes cemilan yang mengenyangkan untuk penderita diabetes research an overview Although no single animal model replicates all aspects of diabetes mellitus in humans animal models are essential for the study of energy balance and metabolism control as well as to investigate the reasons for their imbalance that could eventually lead to overt metabolic diseases such as type 2 di Mammalian models of diabetes mellitus with a focus on type 2 diabetes The animal models of type 2 diabetes can be obtained either spontaneously or induced by chemicals or dietary or surgical manipulations andor by combination thereof In recent years large number of new genetically modified animal models including transgenic generalized knockout and tissuespecific knockout mice have been engineered for the Mammalian models of diabetes mellitus with a focus on type 2 PubMed Rationale for Use of Animal Models for Diabetes Mellitus The two major forms of diabetes are type 1 formerly termed juvenileonset diabetes and type 2 formerly termed adultonset diabetes Type 2 diabetes T2D 1 is the most common form which represents more than 90 of all cases Regardless of the classification the resulting metabolic ences that increase the risks of type 2 diabetes and testing of various therapeutic agents The animal models of type 2 diabetes can be obtained either spontaneously or induced by chemicals or dietary or surgical manipulations andor by combination thereof In recent years large number of new genetically modified animal models including transgenic generalized knockout and tissuespecific This review gives an overview on the animal models of type 2 diabetes with reference to their originsource characteristic features underlying causesmechanism advantages and disadvantages to the investigators in diabetes research Type 2 diabetes mellitus riskesdas diabetes is a complex and heterogeneous disorder presently affecting more than 100 million people worldwide and causing serious socioeconomic problems The most frequently used large animal models include pigs dogs and cats most diabetic cats have a disease entity similar to human type 2 diabetes mellitus whereas in most diabetic dogs the The Zucker diabetic fatty ZDF rats are a type of experimental animal model that reflects type 2 diabetes of human form These rats originated from a colony of outbred zucker rats in Walter Shaws laboratory in Indianapolis USA Genetic model of the zucker diabetic rat was established in 1991 Experimental animal models for diabetes and its related complicationsa animal models of type 2 diabetes can be obtained either spontaneously or induced by chemicals or dietary or surgical manipulations andor by combination thereof In recent years large number of Animal Models of Type 2 Diabetes Clinical Presentation and Animal models in type 2 diabetes research An overview LWW Most type 2 diabetes animal models used today are obese because type 2 diabetes and obesity are strongly related Genetic engineering or naturally occurring mutations may result in obesity Srinivasan K Ramarao P Animal models in type 2 diabetes research an overview Indian J Med Res 2007125451472 Google Scholar 54 PDF Animal models in type 2 diabetes research An overview Experimental diabetic animal models to study diabetes and diabetic Animal models in type 2 diabetes research an overview Semantic Scholar This review gives an overview on the animal models of type 2 diabetes with reference to their originsource characteristic features underlying causesmechanisms advantages and disadvantages Animal models in type 2 diabetes dokter diabetes research An overview K
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