antidepressant and diabetes - Purpose of review Depression and diabetes diabetes mellitus and hypertension ppt mellitus type 2 DM2 are frequently comorbid conditions It is of considerable clinical significance to avoid metabolic risks in nondiabetic depressed patients and to consider effects on glucose regulation in depressed DM2 patients This review is an overview on antidepressant treatment and its Antidepressant Medication as a Risk Factor for Type 2 Diabetes and Diabetes and depression Coping with the two conditions Antidepressant medication use has risen sharply over recent years with 467 million prescriptions for antidepressants issued in the UK in 2011 compared with 201 million in 1999 Recently there have been concerns that antidepressants may adversely affect glucose metabolism not least because some antidepressants induce significant weight gain which may contribute to insulin resistance Purpose of review Depression and diabetes mellitus type 2 DM2 are frequently comorbid conditions It is of considerable clinical significance to avoid metabolic risks in nondiabetic depressed patients and to consider effects on glucose regulation in depressed DM2 patients This review is an overview on antidepressant treatment and its potential metabolic risks Effects of antidepressants on glucose metabolism and diabetes PubMed Antidepressant Medication as a Risk Factor for Type 2 Diabetes and The association between Diabetes mellitus and Depression J Med Life 201692120125 Holt RIG de Groot M Golden SH Diabetes and depression Curr Diab Rep 2014146491 doi 101007s1189201404913 Brieler JA Lustman PJ Scherrer JF et al Antidepressant medication use and glycaemic control in comorbid type 2 diabetes and depression Among patients with newonset type 2 diabetes after antidepressant use data were extracted for those who were not prescribed an antidiabetes drug had 2year followup data on antidepressant prescription status and had changes in HbA 1c capella university diabetes flexpath level after type 2 diabetes onset These patients were then divided into three groups according to Effects of antidepressants on glucose metabolism and diabetes mellitus To conclude that diabetes is a consequence of antidepressant use the drug must be prescribed before the onset of diabetes Although this occurs in the case histories cohort and experimental studies in other studies diabetes preceded antidepressant use with evidence of reverse causality Association Between the Use of Antidepressants and the Risk of Type 2 Antidepressants and type 2 diabetes highways to knowns and unknowns Antidepressants and type 2 diabetes highways to knowns and unknowns Taking Antidepressants With Type 2 Diabetes Verywell Health Type 2 diabetes T2D is a metabolic disease caused by the development of insulin resistance IR relative insulin deficiency and hyperglycemia Hyperglycemiainduced neurochemical dysregulation activates the progression of depression in T2D Because a bidirectional association between diabetesinsulin resistance and depression has been described in many studies 910111213 an underlying shared pathophysiologic mechanism of depression and type 2 diabetes mellitus T2DM and antidepressant effects of antidiabetic agents have been explored in the field Medications for both diabetes and depression and lifestyle changes can improve both conditions Options include different types of therapy along with regular exercise Collaborative care Treatment supervised by a team of providers that increases therapy when needed helps improve both depression and diabetes Clinical Evidence of Antidepressant Effects of Insulin and Anti Type 2 diabetes T2D is a metabolic disease caused by the development of insulin resistance IR relative insulin deficiency and hyperglycemia Hyperglycemiainduced neurochemical dysregulation activates the progression of depression in T2D patients Therefore management of depression by antidepressant agents improves glucose adekuat obat metformin untuk terapi diabetes homeostasis and insulin sensitivity
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