better sprague dawley wistar compared to diabetes research review - Zucker DiabeticSprague Dawley ZDSD rat Type algorithm diabetes mellitus and chronic kidney disease 2 diabetes Purpose We compared three rat strains to determine if different strains develop earlystage diabetic retinopathy or sensory neuropathy at different rates Methods Sprague Dawley Lewis and Wistar rats were made diabetic with streptozotocin Diabetic and nondiabetic animals had retinal vascular pathology measured at eight months of diabetes Mammalian models of diabetes mellitus with a focus on type 2 diabetes Advancement in genetic manipulation of animal models may result in a quality research product transition to clinical use The treatment of diabetic wounds DWs is always challenging for the medical community because of its multifaceted pathophysiology Due to practical and ethical considerations direct studies of therapeutic interventions on Characterization of Diabetic Neuropathy in the Zucker Diabetic Sprague Sprague Dawley Lewis and Wistar rats were made diabetic with streptozotocin Diabetic and nondiabetic animals had retinal vascular pathology measured at eight months of diabetes All experiments followed the guidelines set forth by the Association for Research in Vision and Ophthalmology Resolution on Treatment of Animals in Research The Highfat dietinduced obesity Rat model a comparison between Wistar Recently a new rat model for type 2 diabetes the Zucker diabetic SpragueDawley ZDSDPco was created 5 Fraternal Order of Eagles Diabetes Research Center University of Iowa Iowa City IA 52242 USA Find articles by Mark A Yorek Compared to SpragueDawley rats at 34 weeks of age ZDSD rats were hyperlipidemic as indicated by Animal models for induction of diabetes and its complications The effects of rat strain and gender in in vitro metabolism were investigated in Sprague Dawley SD and Wister Han WH rats based on the hepatocyte metabolic profiles of 14 small molecule drugs Similarities were found between the hepatocyte metabolic clearances of SD and WH strains suggesting that only one strain can apakah penderita diabetes boleh minum air kelapa be confidently used for What is the topic of this review The Zucker DiabeticSprague Dawley ZDSD rat is in the early adoption phase of use by researchers in the fields of diabetes including prediabetes obesity and metabolic syndrome serum glucose concentrations were higher in ZDSD on Purina 5008 compared with SpragueDawley 2012 Tubular markers With an emphasis on the animal models of diabetes induction this review provides a basic overview of diabetes and its various types Albuminuria increases by 10 times in Wistar rats 1 week after STZ induction and by 400fold in Sprague Dawley rats 6 weeks after STZ induction summary and comparison J Diabetes Res 2013 2013 p A study using outbred SpragueDawley rats showed that when compared with dams that were maintained on lowfat chow during pregnancy and lactation females exposed to a highenergy diet gained Comparison of three strains of diabetic rats with respect to the rate Experimental animal models for diabetes and its related complicationsa Preclinical models of diabetic wound healing A critical review Comparison of three strains of diabetic rats with respect to the rate Comparative assessment for rat strain differences in metabolic profiles However a direct comparison between Wistar and SpragueDawley SD Rat as models of highfat HF dietinduced obesity has not been adequately evaluated so far Wistar and SD rats were assigned for 2 experimental groups for 17 weeks standard St and highfat HF diet groups To assess some of the features of the metabolic syndrome oral Some of the animals employed in diabetes research and the methods of induction of diabetes in the animals are discussed below strain is formed by mating an unconstrained hypertensive female rodent of the KyotoWistar strain with a normotensive SpragueDawley male These models are widely employed for the penderita diabetes bolehkah minum susu cap beruang study of relationship between
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