central obesity smoking alcohol diabetes - Genetic Predisposition to Central Obesity and Risk of Type 2

central obesity smoking alcohol diabetes - Lipids as the link between central what is difference in type 1 and 2 diabetes obesity and diabetes Genetic Predisposition to Central Obesity and Risk of Type 2 Obesity Diabetes and Cardiovascular Diseases A Compendium Traditional risk factors including male sex hypertension hyperlipidemia obesity and current smoking were more prevalent in subjects with diabetes than in those without diabetes Compared with nondiabetics diabetics had higher levels of triglycerides glucose AIP TyG index and HbA1C but had lower levels of HDLC and LDLC all P 005 Central obesity and normalweight central obesity among Central obesity was significantly associated with hypertension but not associated with diabetes among those with normal weight by BMI Female sex age over 30 years marriage secondary or tertiary level of education nonsmoking status diabetes and hypertension significantly predicted central obesity among the study participants Conclusion Alcohol Consumption and Obesity An Update PMC Central fatness and risk of all cause mortality systematic Association of Central Obesity With All Cause and Cause As a result smoking increases the risk of metabolic syndrome and diabetes and these factors increase risk of cardiovascular disease In the context of the worldwide obesity epidemic and a high prevalence of smoking the greater risk of central obesity and insulin resistance among smokers is a matter of major concern Introduction Genetic Predisposition to Central Obesity and Risk of Type 2 Results Our results suggest that normalweight central obesity is associated with an increased risk of DM OR 237 95 CI 175323 compared with normalweight participants without central obesity Association of combined body mass index and central obesity To assess whether alcohol consumption decreases during an intensive lifestyle intervention ILI and whether alcohol consumption is associated with weight loss among participants with overweightobesity and type 2 diabetes The impact of smoking on the development of diabetes and its Among the overweightobese women exsmokers β 273 199 346 and heavy daily smokers β 490 335 644 had the highest estimates for WC when adjusted for age BMI alcohol consumption and physical activity Moderate alcohol use may be associated with lower risk of type 2 diabetes mellitus T2DM Previous reviews have reached mixed conclusions Purpose To quantify the doseresponse relationship between alcohol consumption and T2DM accounting for differential effects by sex and BMI Data Sources Background Diabetes is a major public health issue and over half a billion people are estimated to be living with diabetes with 67 million deaths reported in 2021 The global diabetes burden has been recognised and included in the United Nations Sustainable Development Goals to achieve a zero increase in diabetes cases and reduce onethird of premature diabetes deaths by 2030 However Background Sex differences exist in type 2 diabetes T2D and androgens have been implicated in the etiology of T2D in a sexspecific manner We therefore aimed to investigate whether androgens play a role in explaining sex differences in glucose homeostasis and incidence of T2D Methods We used observational data from the German populationbased KORA F4 study n 1975 mean age 54 years The Relationship Between Alcohol Consumption BMI and Type 2 Observational studies indicate that moderate levels of alcohol consumption may reduce the risk of type 2 diabetes In addition to providing an updated summary of the existing literature this metaanalysis explored whether reductions in risk may be the product of misclassification bias RESEARCH DESIGN AND METHODS Normalweight central obesity implications for diabetes Prediction model for identifying highrisk groups for Different associations of atherogenic index of plasma After adjusted for age gender education marital status smoking status alcohol intake social activity hypertension dyslipidemia diabetes depression nine chronic diseases and selfrated health participants with central obesity normal BMI had a 279 higher risk hazard ratio HR 1279 95 confidence interval diabetes before after CI 10741524 of Conclusions Indices of central fatness including waist circumference waisttohip ratio waisttoheight ratio waisttothigh ratio body adiposity index and A body shape index independent of overall adiposity were positively and significantly associated with a higher all cause mortality risk Joint effects of BMIGRS and WHRGRS on risk of T2D Data are pooled from women and men and adjusted for age genotype data source family history of diabetes smoking alcohol intake menopausal hormone therapy use women only Healthy Eating Index and total energy intake Alcohol Intake and Weight Loss during an Intensive Lifestyle Purpose This study was aimed to build a prediction model to identify highrisk groups for overweight or obesity among Korean men in their 30s and 40s Methods This study analyzed data from 28388 men aged 3040 years gathered in the 2022 Community Health Survey Participants were categorized into two groups based on BMI underweightnormal weight group and overweightobese group This study Recently a doseresponse metaanalysis involving 72 prospective cohort studies reported a nearly Jshaped association between central obesity indices and all cause mortality 17 however the potential effects of reverse causality were not restricted We adjusted for the possible confounding effects of age sex physical activity alcohol consumption and the presence of hypertension or diabetes RESULTS A statistically significant difference in central obesity according to smoking status was identified Relationship of normalweight central obesity with the risk Smoking status and abdominal obesity among normal and Many epidemiological studies have shown that smoking is independently associated with an increased risk of central obesity 13 Central obesity is a wellestablished risk factor for insulin resistance and diabetes Associations of smoking with overall obesity and central OBJECTIVE The International Diabetes Federation IDF proposes that central obesity is an essential component of the metabolic syndrome while the American Heart AssociationNational Heart Lung and Blood Institute AHANHLBI proposes that central obesity is an optional component Should Central Obesity Be an Optional or Essential Component Compared with normalweight non central obesity obese non central obesity men n 373 have a decreased risk of diabetes OR 053 95 CI 030091 while obese non central obesity women n 24 have an increased risk of diabetes OR 239 95 CI 0471211 Our analysis of a nationwide health checkup and administrative claims database including 17 million participants without prevalent CVD history demonstrated the potential impact of NWCO on the risk for HF and AF suggesting the importance of abdominal obesity in the developing HF and AF even in normalweight individuals The mediatory role of androgens on sex differences in glucose Community beliefs and practices about diabetes and their Alcohol Consumption and the Risk of Type 2 Diabetes A Normalweight central obesity implications for diabetes mellitus Within this escalating healthcare problem of monumental proportions obesityassociated type 2 diabetes accounts for 9095 of all diagnosed diabetes in adults 1 In fact diabetes and insulin resistance are powerful predictors of cardiovascular morbidity and mortality and each is an independent risk factor for death in patients with heart fail Although moderate alcohol use is recommended excessive alcohol consumption is the third leading cause of premature death in the United States behind smoking and obesity Abdominal obesity is a major risk factor for type 2 diabetes T2D We aimed to examine the association between the genetic predisposition to central obesity assessed by the waisttohip ratio WHR genetic score and T2D risk Consequences of smoking for body weight body fat These findings offer new insights into the potential mechanisms linking central obesity and diabetes risk and suggest novel approaches for the general population to prevent or manage the risk of diabetesrelated to central obesity by controlling diabetes and calling in sick metabolic factors like dyslipidemia

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