choline diabetes - New Research Explores Choline Metabolites and synjardy diabetes LongTerm Diabetes Risk Diet is the primary source of gut microbiota metabolites however little is known about the association between dietary phosphatidylcholine and risk of type 2 diabetes T2D We extracted data with dietary intake from three ongoing cohorts the Nurses Health Study NHS NHS II and the Health Professionals FollowUp Study HPFS Dietary Phosphatidylcholine Intake and Type 2 Diabetes in Men and Women Dietary intake of choline and phosphatidylcholine and risk of type 2 Choline is a macronutrient thats important for liver function normal brain development nerve function muscle movement supporting energy levels and maintaining a healthy metabolism It commonly develops with people who have an excessive alcohol intake are obese suffer with diabetes or a form of insulin resistance and have other Relationship between dietary choline intake and diabetes mellitus in The Association of Dietary Choline and Betaine With the Risk of Type 2 Cholines Neutral Role Choline itself showed no clear association with diabetes risk suggesting it may not be a predictor of the disease Study Design The research is part of the ongoing CARDIA study which follows a diverse group of adults and focuses on investigating the determinants of cardiovascular disease and risk factors throughout Recent studies have related plasma levels of gut microbiota metabolites of dietary phosphatidylcholine to risk of cardiovascular disease 12Choline from dietary phosphatidylcholine can be converted by gut microbes to form trimethylamine which is then absorbed and oxidized in the liver to form trimethyamine oxidase Diet is the primary source of gut microbiota metabolites however little Type 2 diabetes In three large cohorts of men and women higher intakes of phosphatidylcholine were associated with an increased risk of type 2 diabetes mellitus T2DM 9 Those who had the highest dietary intakes of choline showed a 34 increased risk of T2DM compared with the lowest intakes The Association of Dietary apa hubungan diabetes melitus dengan lumpuhnya anggota gerak Choline and Betaine With the Risk of Type 2 Background Little is known about the relationship between dietary intake of choline which is a major dietary precursor for gut microbiomederived trimethylamine Noxide TMAO and diabetes mellitus DM in the general population The present study aims to explore the relationship between dietary choline intake and DM in the US adult population Dietary Phosphatidylcholine Intake and Type 2 Diabetes in Men and Women What is Choline Big Benefits Signs of a Deficiency Dr Axe Choline Metabolites and 15Year Risk of Incident Diabetes in a Similarly comparing those in the highest quartile of dietary choline intake with those in the lowest quartile there was no significant association between dietary choline intake and the risk type 2 diabetes HR 109 95 CI 084 142 nor was dietary betaine intake significantly associated with the risk of type 2 diabetes comparing the highest to the lowest quartile HR 106 95 CI 087 Elevated blood TMAO concentration has been implicated as a risk factor for atherosclerosis cardiovascular disease kidney disease and mortality and also for type 2 diabetes T2D 2 3 Because choline is a major precursor for TMAO high choline intake could have an adverse impact on T2D risk In crosssectional analyses choline and TMAO have been positively associated and betaine inversely associated with prevalent diabetes fasting glucose HbA 1c and HOMA of insulin resistance HOMAIR 2461112In prospective studies betaine has remained inversely associated with incident diabetes while choline and TMAO associations are often attenuated 810111314 Among women there was a higher risk of type 2 diabetes comparing the highest to lowest dietary choline quartile HR 154 106 225 while in men the association was null HR 082 057 117 Nevertheless there was a nonsignificant interaction between high choline intake and sex on the risk of type 2 diabetes P 007 The results diabetes penyebab kematian Choline The Nutrition Source
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