clinical implications of pharmacogenetics for diabetes - Pharmacogenetics addresses the impact of genetic riwayat keluarga diabetes melitus variants on treatment outcome including sideeffects In recent years it has also entered the field of clinical diabetes research In modern type 2 diabetes therapy metformin is established as firstline drug Future Medications for Obesity and Clinical Implications Identification of druggenotype interactions in pharmacogenetic studies of the OAD treatment might have clinical implications in the near future resulting in selection of more specific personalized therapy in T2DM In this review we evaluated the pharmacogenetic evidences currently available in the literature and we identified the top informative genetic variants associated with response to the most common antidiabetic drugs metformin DPP4 inhibitorsGLP1R agonists thiazolidinediones and sulfonylureasmeglitinides Pharmacogenetic studies update in type 2 diabetes mellitus Pharmacogenetics in type 2 diabetes precision medicine or The aim of this article is to summarize recent progress and discoveries for T2D pharmacogenetics and to discuss the factors which limit the furthering accumulation of genetic variability knowledge in patient response to therapy that will allow improvement the personalized treatment of T2D The clinical utility of genetic variation for tailoring diabetes medications rests on the identification of substantial and statistically significant pharmacogenetic interactions from internally valid studies and confirmation of their findings in varied populations based on raceethnicity Pharmacogenomic Studies of Current Antidiabetic Agents and This review summarizes pharmacogenomic evidence of some current antidiabetic agents applied in clinical settings and highlights potential drugs with new targets for diabetes which represent a more effective treatment in the future Keywords Diabetes New targets Pharmacogenomics Precision medicine Key Summary Points The identification of extreme sulfonylurea sensitivity in patients with diabetes mellitus owing to heterozygous mutations in HNF1A represents a clear example of how pharmacogenetics can direct Current progress in pharmacogenomics of Type 2 diabetes A Despite the availability of at least 10 drug classes for the treatment of T2D metformin remains the most widely used firstline pharmacotherapy for its treatment however marked interindividual variability in response and few clinical or biomarker predictors of response reduce its optimal use Pharmacogenetic findings may aid in identifying new drug targets elucidate pathophysiology unravel disease heterogeneity help prioritise specific genes in regions of genetic association and contribute to personalised or precision treatment Pharmacogenetic Studies in Type 2 Diabetes Type 2 diabetes mellitus is a chronic metabolic disease resulting from insulin resistance and progressively reduced insulin secretion which leads to impaired glucose utilization dyslipidemia and hyperinsulinemia and progressive pancreatic beta cell dysfunction Explore our catatan international diabetes f 2018 indonesi site to get educated on the latest diabetes news research more Vertexs commitment to patients has revolutionized T1D research and patient care T1D Patient Care Diabetes research This review summarizes the genetics and pathophysiology of T2DM candidategene approaches genomewide association studies personalized medicine clinical relevance of pharmacogenetic variants associated with oral hypoglycemic agents and paths toward personalized diabetology Pharmacogenetics Implications for Modern Type 2 Diabetes Pharmacogenetics of Type 2 DiabetesProgress and Prospects Pharmacogenetics in type 2 diabetes potential implications Videos for Clinical Implications Of Pharmacogenetics For Diabetes Semaglutide and tirzepatide have recently been approved for obesity and found to achieve 15 weight loss in clinical trials These drugs have been referred to as secondgeneration medications because the unprecedented degree of weight loss they afford is sufficient to treat or prevent a broad array of obesity complications and related diseases Metformin Pharmacogenomics Current Status and Future Pharmacogenetics pharmacogenomics and diabetes There is great variability in drug response whether measured in terms of efficacy or toxicity Pharmacogenetics of type 2 diabetes mellitus the route Pharmacogenetic findings may help to uncover new drug targets illuminate pathophysiology clarify disease heterogeneity aid in the finemapping of genetic associations and contribute to personalized treatment Pharmacogenetics of Type 2 DiabetesProgress and Prospects Diabetes Is There a Future for Pharmacogenomics Guided Pharmacogenomics in type 2 diabetes oral antidiabetic drugs Pharmacogenetics and personalized treatment of type 2 diabetes The Pharmacogenetics of Type 2 Diabetes A Systematic Review This review outlines the robust evidence accrued to date for pharmacogenetics of metformin sulfonylureas thiazolidinediones and dipeptidyl peptidase4 inhibitors but highlights that these variants will only be of clinical utility when the genotype is already known at the point of prescribing For different biological and nonbiological reasons strong interindividual differences in the clinical response to OAD treatment have been observed in terms of antihyperglycemic outcome Pharmacogenetics in type 2 diabetes potential implications Older antidiabetic medications such as metformin sulfonylurea and TZDs have significantly more pharmacogenomics studies than the newer drugs such as GLP1 RA DPP4i and SGLT2 inhibitors With more genetic markers being identified further advancements in diabetes clinical practice will almost certainly ensue Pharmacogenomics and Personalized Medicine in Type 2 Diabetes Clinical utility of pharmacogenetic study is to predict the therapeutic dose of various OADs on individual basis Pharmacogenetics therefore is a step towards 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