cmd diabetes melitus - Diabetic patients are frequently affected by penderita diabetes dengan gula darah 180mg,apakah normal? coronary microvascular dysfunction CMD a condition consisting of a combination of altered vasomotion and longterm structural change to coronary arterioles leading to impaired regulation of blood flow in response to changing cardiomyocyte oxygen requir Background Coronary microvascular dysfunction CMD is an early feature of diabetic cardiomyopathy which usually precedes the onset of diastolic and systolic dysfunction Continuous intracoronary thermodilution allows an accurate and reproducible assessment of absolute coronary blood flow and microvascular resistance thus allowing the evaluation of coronary flow reserve CFR and Coronary microvascular dysfunction CMD has been proposed as an important component of diabetes mellitus DM and hypercholesterolemiaassociated coronary artery disease CAD Previously we observed that 25 mo of DM and highfat diet HFD in swine blunted bradykinin BKinduced vasodilation an Abstract 14425 Coronary Microvascular Disease in Type 2 Diabetes is Lack of correlation between the optimal glycaemic control and coronary Coronary Microvascular Dysfunction in Diabetes Mellitus Pathogenetic Occult coronary microvascular dysfunction and ischemic heart disease in Background Patients with type 2 diabetes mellitus are at an increased risk of adverse cardiovascular events compared to those without diabetes The timing relative to disease onset and degree of glycemic control that reduces the risk of adverse cardiovascular events remains uncertain Coronary microvascular dysfunction is prevalent in patients with type 2 diabetes mellitus and is linked to Prognostic value of coronary microvascular dysfunction assessed by Patients with diabetes mellitus DM and heart failure HF have worse outcomes than normoglycemic HF patients Cardiovascular magnetic resonance CMR can identify ischemic heart disease IHD and quantify coronary microvascular dysfunction CMD using myocardial perfusion reserve MPR We aimed to quantify the extent of silent IHD and CMD in patients with DM presenting with HF Diabetes mellitus DM is a diabetes dan kencing manis apakah sama common risk factor for ischemic heart disease and its prevalence is increasing globally 1 2There is clear evidence that DM is associated with adverse cardiovascular risk and mortality in patients with the chronic coronary syndrome CCS 3456Coronary microvascular dysfunction CMD is a clinical condition where the structure andor function of coronary Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Diabetes mellitus is a prominent risk factor of coronary microvascular disease CMD and the comorbidity of CMD in diabetic patients leads to an increasing occurrence of cardiac mortality Increased protein Olinked βNacetylglucosaminylation OGlcNAcylation a posttranslational modification of proteins is implicated in the development of vascular complications in diabetes Coronary microvascular dysfunction CMD is associated with cardiovascular events in type 2 diabetes mellitus T2DM Optimal glycaemic control does not always preclude future events We sought to assess the effect of the current target of HBA1c level on the coronary microcirculatory function and identify predictive factors for CMD in T2DM 2 Pathophysiology of CMD in Diabetes Endothelial dysfunction associated with diabetes is the most likely primary originating cause of CMD This process was long ago indicated by the impaired coronary microvascular response to intracoronary acetylcholine infusion and to sympathetic stimulation by cold pressor test in diabetic subjects without significant CAD and was clearly documented as an Coronary microvascular dysfunction after longterm diabetes and Coronary microvascular dysfunction is associated with poor glycemic Microvascular Dysfunction in Patients With Type II Diabetes Mellitus Coronary Microvascular Dysfunction in Diabetes Mellitus PubMed DM diabetes mellitus CMD cardiometabolic disease Current evidence suggests that breakdown of the BNB plays a pivotal role in the pathogenesis of DSPN The BNB consists of the endoneurial microvessels within the nerve fascicle and the investing perineurium providing a selective bloodtissue interface odor in urine diabetes within the peripheral nerve
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