coleus amboinicus diabetes gene - Several phytoconstituents from various phytochemical classes fingernails and diabetes such as phenolics terpenoids phenolic acids flavonoids flavones and tannins have been identified in Coleus amboinicus up to the present time Traditional Uses Phytochemistry and Pharmacological In Silico Molecular Docking Studies of Phytocompounds From In Silico Molecular Docking Studies of Phytocompounds From The enzyme Glucokinase GCK which is present mainly in the liver and beta cells of the pancreas is involved in maintaining blood glucose homeostasis Hence the present in silico study is designed to determine the interaction between GCK and compounds ligands of Coleus amboinicus Coleus amboinicus sometimes referred to as Indian Borage is described along with its pharmacological properties traditional uses medicinal applications side effects and method of treating typhoid 21 Coleus aromaticus a therapeutic herb with multiple potentials The potential effect of Torbangun Coleus amboinicus Lour leaves extract in decreasing of blood glucose levels and glutathione peroxidation activities in hyperglycemic rats model Meilla Dwi Andrestian1 Rizal Damanik3 Faisal Anwar2 Nancy Dewi Yuliana4 1 Department of Nutrition Poltekkes Kemenkes Banjarmasin Indonesia Traditional Uses Phytochemistry and Pharmacological In Silico Molecular Docking Studies of Phytocompounds From Extract of Torbangun Coleus amboinicus Lour Leaves Inhibits Understanding how glucokinase interacts with the molecules in Coleus amboinicus is the aim of this study This study will advance knowledge of the glucokinase activation mechanism and pave the road for the creation of novel GCKAs that could specifically stimulate GCK in the treatment of T2DM Antihyperglycemic Effect of Torbangun Coleus amboinicus The potential effect of Torbangun Coleus amboinicus Lour Pathorchur Coleus aromaticus A review of the medicinal C aromaticus has the property to act against diabetes and acts towards αamylase enzyme inhibition Warrier et al Citation 1996 The essential oil extracted from C aromaticus leaves and the bioactive constituent Carvacrol positively inhibited diabeteslinked αamylase and αglucosidase Bole and Jayashree Citation 2014 AREVIEW OF PHYTOCHEMICAL MEDICINAL AND NUTRITIONAL IJFANS Furthermore transcriptional profiling was conducted to unveil the overall patterns of gene expression and the differential expression of genes involved in motility curli fimbriae and invasion was verified using quantitative reverse transcription PCR qRTPCR Effects of Torbangun LeavesColeus amboinicus Lour Extract In Silico Molecular Docking Studies of Phytocompounds From MODY represents less than 2 of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus At least 13 MODY subtypes extrapancreas diabetes with distinct genetic etiologies have been Numerous pharmacological properties of Coleus amboinicus crude extracts have been documented through both in vitro and in vivo studies including but not limited to antitumor antibacterial Transcriptional Profiling of the Effect of Coleus amboinicus ABSTRACT Torbangun leaf extract TLE in hyperglycemic rats by observing its effect on blood glucose lev ls and PEPCK and G6Pase gene expression Method This posttestcontrolled group design study used a co pletely randomized design CRD Seven rats were separated as a normal gro Andrestian et al 2019b explained that the restoration of bcell structure allows increased insulin production stimulated by changes in glucose homeostasis gene expression namely increased The herb Coleus aromaticusamboinicus belong to the botanical family Lamiaceae Labiatae and Coleus now referred as Plectranthus genus It is a large succulent aromatic perennial herb with approximately 3090 cm in height and with thick fleshy stem and leaves molecular docking model has been used to confirm the antidiabetic efficiency of Coleus amboinicus compounds Table 1 The molecular docking investigation was carried out using AutoDock Vina in PyRx 08 Herbal drugs are prescribed in treatment of diabetes mellitus due to their good effectiveness fewer side effects in clinical experience and relatively low costs Screening of antidiabetic therapeutics is very important and essential for effective management of diabetes mellitus Coleus aromaticus Benth an update on its bioactive amboinicus and Punica granatum was shown to exhibit good wound healing properties in laboratory mice Further ethanolic extract of P amboinicus reduced the wound area by up to 766 in diabetic mice induced by monosodium glutamate Plectranthus amboinicus Lour Spreng Botanical In Silico Molecular Docking Studies of Phytocompounds From Coleus amboinicus Benth also known as Plectranthus amboinicus Lour Spreng is a perennial plant from the Lamiaceae family commonly found in tropical and warm regions of Africa Asia and Australia Folk medicine commonly employs this remedy to address various ailments including Plectranthus Species with AntiInflammatory and Analgesic Antihyperglycemic Effect of Torbangun Coleus amboinicus Lour Leaves Extract Through Liver and Muscle Glycogen Deposits in Streptozotocininduced Hyperglycmic SpragueDawley Rats Model Professor Rizal Damanik PhD Medical Laboratory Technology Journal amboinicus also showed diuretic effects associated with improved electrolyte balance These results emphasize the effectiveness of this species in metabolic diseases such as hypertension and diabetes which stand out buku ajar diabetes melitus terbaru as public health problems
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