complication in diabetes pathophysiology - Causes of Diabetes Complications Most complications obat diabetes dr zaidul akbar of diabetes are the result of problems with blood vessels Glucose levels that remain high over a long time cause both the small and large blood vessels to narrow The narrowing reduces blood flow to many parts of the body leading to problems New insights into diabetes mellitus and its complications a narrative The Pathobiology of Diabetic Complications Diabetes American However overt hyperglycemia needs to be addressed to avoid acute complications of diabetes and a catabolic state Comorbidities Kidney Impairment Kidney impairment is a prevalent complication of diabetes It is also an independent comorbidity very often caused by vascular complications in people with type 2 diabetes The general features of hyperglycemiainduced tissue damage are shown schematically in Fig 1The DCCT Diabetes Control and Complications Trial and the UKPDS UK Prospective Diabetes Study established that hyperglycemia shown on the far left of the figure is the initiating cause of the diabetic tissue damage that we see clinically shown on the far right 12 Differentiation of Diabetes by Pathophysiology Natural History and Pathoph ysiology of diabetes mellitus and its complications Metabolic events and contr ol Franklyn O Ohiagu 1 P aul C Chikezie 1 Chinwendu M Chikezie 2 Complications of Diabetes Mellitus The Merck Manuals Diabetes and Complications of Diabetes Pathophysiology Mechanisms Complications of Diabetes Mellitus MSD Manuals Complications of Diabetes PMC PubMed Central PMC Using both candidate gene and GWAS approaches hundreds of genes and genetic loci associated with type 1 diabetes type 2 diabetes gestational diabetes mellitus and diabetic complications have been discovered PDF Pathophysiology country rank worldwide diabetes mellitus prevalence 2017 pdf of diabetes mellitus complications Metabolic Diabetes causes significant macrovascular complications such as coronary artery disease peripheral artery disease and stroke Longterm complications of diabetes are development of retinopathy with potential loss of vision nephropathy with endstage renal disease neuropathy with a potential for foot infections and amputation and macro In patients with diabetes mellitus years of poorly controlled hyperglycemia lead to multiple primarily vascular complications that affect small vessels microvascular large vessels macrovascular or both The mechanisms by which vascular disease develops include Glycosylation of serum and tissue proteins with formation of advanced glycation end products Complications of Diabetes Mellitus an overview ScienceDirect Diabetes is justly recognized as an emerging global epidemic representing one of the leading causes of morbidity and mortality worldwide Hyperglycemia the common characteristic of both type 1 diabetes mellitus T1DM and type 2 diabetes mellitus T2DM has the potential to cause serious complications due to its insidious and chronic nature Dyslipidemia is also a common complication of diabetes Apolipoprotein M apoM as a novel apolipoprotein may be related to the development and progression of diabetes which need to further investigation Obstructive sleep apnea OSA is another common complication of diabetes and is an independent risk factor for cardiovascular disease CVD Protective Factors and the Pathogenesis of Complications in Diabetes Diabetes causes myriad pathologies in many organ systems which is not unexpected since it causes significant abnormalities in almost all metabolic pathways of cells The chronic complications of diabetes are generally due to insulin deficiency or insulin resistance in combination with persistent hyperglycemia gejala diabetes muntah-muntah and dyslipidemia and disorders
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