coppleters 2012 diabetes - Diabetes Care 201235327333 PMC free article what is another name for type 2 diabetes Google Scholar 10 Sato Y Ouchi K Funase Y Yamauchi K Aizawa T Relationship between metformin use vitamin B12 deficiency hyperhomocysteinemia and vascular complications in patients with type 2 diabetes Endocr J 20136012751280 Google Scholar 11 PDF Virus Infections in Type 1 Diabetes CSHL P A concise summary of data obtained in mouse models and humans is provided to identify future avenues toward a better characterization of the association between viruses and T1D and suggests potential relationships may be more complex than previously thought The precise etiology of type 1 diabetes T1D is still unknown but viruses have long been suggested as a potential environmental trigger Demonstration of Isletautoreactive CD8 T Cells in Insulitic Lesions Immunology in the clinic review series focus on type 1 diabetes and Convincing evidence now indicates that viruses are associated with type 1 diabetes T1D development and progression 2012 Apr1681 101111j13652249201104554x Authors K T Coppieters 1 A Wiberg S M Tracy M G von Herrath Affiliation 1 Type 1 Diabetes Center The La Jolla Institute for Allergy and Immunology La Jolla CA Type 1 diabetes T1D is a disease characterized by inflammation of pancreatic islets associated with autoimmunity against insulinproducing beta cells leading to their progressive destruction The condition constitutes a significant and worldwide problem to human health particularly because of its rapid but thus far unexplained increase in Viral infections and molecular mimicry in type 1 diabetes Coppieters A direct association of isletautoreactive T cells with β cell destruction in human pancreatic islets from type 1 diabetes T1D patients has never been demonstrated and little is known about disease progression after diagnosis Epub 2012 Jan 2 Authors Ken T Coppieters 1 Francesco Dotta Natalie Amirian Peter D Campbell Thomas W H Coppieters KT Dotta F Amirian N mediq diabetes contact Campbell PD Kay TW Atkinson MA et al Demonstration of IsletAutoreactive CD8 T Cells in Insulitic Lesions From Recent Onset and LongTerm Type 1 Diabetes Patients J Exp Med 2012 209 15160 101084jem20111187 PMC free article Google Scholar Longterm Metformin Use and Vitamin B12 Deficiency in the Diabetes Type 1 Diabetes RD Center Novo Nordisk Inc Seattle WA USA Type 1 Diabetes Center La Jolla Institute for Allergy and Immunology La Jolla CA USA Correspondence to Matthias von Herrath Type 1 Diabetes Center La Jolla Institute for Allergy and Immunology 9420 Athena Circle La Jolla CA 92037 USA email email protected Search for Identifying New Hybrid Insulin Peptides HIPs in Type 1 Diabetes Demonstration of isletautoreactive CD8 T cells in insulitic lesions Type 1 diabetes T1D development is associated with inflammation of the pancreatic islets and the presence of leukocyte infiltrates insulitis has long served as a hallmark in differentiating the disease from other forms of diabetes Gepts 1965The histological composition of islet infiltrates includes B cells macrophages and NK cells but is typically dominated by CD8 T cells Coppieters Virus Infections in Type 1 Diabetes Ken T Coppieters Tobias Boettler and Matthias von Herrath Center for Type 1 Diabetes Research La Jolla Institute for Allergyand Immunology La Jolla Cite this article as Cold Spring Harb Perspect Med 20122a007732 3 wwwperspectivesinmedicineorg A more ambiguous role is reserved for coxsackie B PDF Virus infections in type 1 diabetes Semantic Scholar Antibody crossreactivity and the viral aetiology of type 1 diabetes Exploring an isletprotective role for native pancreatic mesenchymal stromal cells in health and in type 1 diabetes Quantitative proteomic profiling of human islets in healthy and diabetes associated pregnancy Identification of protective niches in T1D pancreata 0001 Dynamic scRNAseq Archives Demonstration of isletautoreactive CD8 T kurma dan diabetes cells in insulitic lesions
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