defronzo diabetes 1992 diabetes care - Efficacy of Metformin in Patients with susu kental manis untuk diabetes NonInsulinDependent Metabolic and Molecular Pathogenesis of Type 2 Diabetes Introduction Diabetes Care American Diabetes Association In Brief Impaired insulin secretion increased hepatic glucose production and decreased peripheral glucose utilization are the core defects responsible for the development and progression of type 2 diabetes Pathogenesis of type 2 noninsulin dependent diabetes Combination therapy in type 2 diabetes mellitus Pathogenesis of Type 2 Diabetes Drugs Springer Pathophysiologic Approach to Therapy in Patients With Newly Treatment of Type 2 Diabetes Mellitus A Rational Approach Latest Issue Alert Ralph A DeFronzo MD Introduction Diabetes Care Volume 15 Issue 9 1 September 1992 Pages 1125 httpsdoiorg102337diacare1591125 Ralph DeFronzo Google Scholar Two general approaches to the treatment of type 2 diabetes mellitus T2DM have been advocated 1 A guideline approach that advocates sequential addition of antidiabetes agents with more established use 1 this approach more appropriately should be called the treat to failure approach and deficiencies with this approach Pathogenesis of type 2 noninsulin dependent diabetes mellitus a balanced overview Diabetologia 1992 Apr35 438997 doi 101007BF00401208 The MultiOrgan Impact of T2DM May Need a Multifaceted Approach to Treatment Check to See Your Patients Eligibility for a Type 2 Diabetes Treatment Pathogenesis of Type 2 noninsulin dependent diabetes During the last hour of the insulin clamp insulinstimulated leg muscle glucose uptake is reduced by 50 in type 2 diabetes 14 These studies support the notion that the primary defect in insulin action in patients with type 2 diabetes resides in the skeletal muscle Skeletal Muscle Insulin Resistance Is the Primary Defect in Pathogenesis of NIDDM A balanced overview PubMed Insulin resistance A multifaceted syndrome responsible for Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes Diabetes Care 2013 Aug36 Suppl 2 Suppl 2S12738 doi 102337dcS132011 Type 2 diabetes mellitus T2DM is a complex metabolic and cardiovascular disorder with at least eight distinct pathophysiologic abnormalities No one antidiabetic agent can reverse all eight of these pathogenic disturbances and successful treatment requires multiple agents used in combination Noninsulindependent diabetes mellitus NIDDM results from an imbalance between insulin sensitivity and insulin secretion Both longitudinal and crosssectional studies have demonstrated that dokter indonesia penemu obat diabetes the earliest detectable abnormality in NIDDM is an impairment in the bodys ability to respond to insulin Noninsulindependent diabetes mellitus NIDDM results from an imbalance between insulin sensitivity and insulin secretion Both longitudinal and crosssectional studies have demonstrated that the earliest detectable abnormality in NIDDM is an impairment in the bodys ability to respond to insulin HCP Official Site Discover T2D Treatment Option Abstract The maintenance of normal glucose homeostasis is dependent on a finely balanced dynamic interaction between tissue muscle and liver sensitivity to insulin and insulin secretion Insulin resistance a multifaceted syndrome responsible for NIDDM obesity hypertension dyslipidemia and atherosclerotic cardiovascular disease RA DeFronzo E Ferrannini Diabetes care 14 Metformin monotherapy and combination therapy with metformin and sulfonylurea are well tolerated and improve glycemic control and lipid concentrations in patients with NIDDM whose diabetes is Glucovance a combination metforminglyburide preparation has recently been approved for use as initial therapy in patients with type 2 diabetes A third drug is required if the HbA 1c exceeds 7 Pathophysiologic approach to therapy in patients with newly Noninsulindependent diabetes mellitus NIDDM results from an imbalance between insulin sensitivity and insulin secretion Both longitudinal and crosssectional studies have demonstrated that the earliest detectable abnormality in NIDDM is an impairment in the bodys ability to respond to insulin Pathogenesis of NIDDM A Balanced Overview Diabetes Care DeFronzo RA Pathogenesis of Type 2 noninsulin dependent diabetes mellitus a balanced overview Diabetologia 35 389397 1992 httpsdoiorg101007BF00401208 Download citation In summary insulin resistance appears to be a syndrome that is associated with a clustering of metabolic disorders including noninsulindependent diabetes mellitus obesity hypertension lipid abnormalities and atherosclerotic cardiovascular disease Nadler JL Malayan S Luong H Shaw S Natarajan R Rude R Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus Diabetes Care 1992 15 835841 Article CAS PubMed Google Scholar Novel Agents for the Treatment of Type 2 Diabetes Pathogenesis of NIDDM A balanced overview Scholars UT Hypertension Cardiovascular Disease Diabetes Mellitus and DeFronzo RA Bonadonna RC Ferrannini E Pathogenesis of NIDDM a balanced overview Diabetes Care 1992 15 31868 Article 4 cara pencegahan diabetes melitus PubMed CAS Google Scholar
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