demyelination cause by diabetes melitus structure - CIDP is a most common chronic lidah buaya untuk obat diabetes immunemediated demyelinating neuropathy but still a rare disease the reported prevalence ranges from 08 to 89 per 100 000 people1 The different prevalence among the studies is partly dependent on diagnostic criteria and CIDP subtypes Currently diagnostic criteria proposed by Joint Task Force of the European Federation of Neurological Societies and the Neuromuscular Complications of Diabetes Mellitus PMC Chronic inflammatory demyelinating polyneuropathy associated with Diabetes mellitus DM is pandemic and is the leading global cause of polyneuropathy most commonly a distal symmetric sensorimotor polyneuropathy DSP By contrast chronic inflammatory demyelinating polyneuropathy CIDP is rare and characterized mainly by symmetrical proximal and distal muscles weakness CIDP and other inflammatory neuropathies in diabetes Nature Chronic Inflammatory Demyelinating Polyneuropathy in Diabetes Patients The pathological hallmarks of diabetic neuropathy are microangiopathy of the vasa nervorum loss of axons and axonal atrophy and demyelination all of which are the result of a combination of different mechanisms of tissue damage that are common to all longterm complications of diabetes The other changes are in the myelination of some of the We reviewed the literature on chronic inflammatory demyelinating polyneuropathy CIDP in diabetes mellitus DM and explored realworld data on the prevalence and treatment of CIDP within DM CSF and nerve biopsy can help rule out other causes for neuropathy and support the Sharma KR Cross J Farronay O Ayyar DR Shebert RT Oxidative stress metabolic abnormalities microangiopathy and other factors caused by diabetes through special signal transduction pathways destroy the normal structure and function of nerve cells and lead to neuronal demyelination and pinaka mabisang gamot sa diabetes neuronal damage which are the main causes of peripheral neuropathy 34 35 Although the most common neuropathy associated with diabetes mellitus is distal symmetric polyneuropathy inflammatory neuropathies such as chronic inflammatory demyelinating polyneuropathy CIDP Diabetic peripheral neuropathy DPN appears frequently in patients diagnosed with type 1 or type 2 diabetes 13The extent of abnormalities is more pronounced if the hyperglycemia is not controlled properly 4 5DPN is associated with deleterious changes in peripheral nerves such as myelin damage and decrease in nerve conduction velocity 49 We report a case of complicated diabetes mellitus developing osmotic demyelination syndrome The patient had presented with altered sensorium and seizure which was initially diagnosed as hyperglycemia but during his treatment the magnetic resonance imaging of brain revealed central pontine myelinolysis Occurrence of osmotic demyelination syndrome in diabetes mellitus A The dilemma of diabetes in chronic inflammatory demyelinating Pathogenesis of Diabetic Neuropathies SpringerLink Diabetesinduced myelin abnormalities are associated with an altered Keywords diabetes mellitus chronic inflammatory demyelination polyneuropathy intravenous immunoglobulin treatment Chronic inflammatory demyelinating polyneuropathy CIDP as the name implies is an autoimmune disorder of unknown etiology in two thirds of the patients however in remaining one third an etiological cause might be found Diabetes mellitus leads to diverse forms of peripheral neuropathy as the major neuromuscular complication Both focal and diffuse types of neuropathy can develop with the most common form being diabetic sensorimotor polyneuropathy Small fibers are damaged early in the development of diabetic sensorimotor polyneuropathy and are not assessed by Frontiers Diabetic peripheral neuropathy pathogenetic mechanisms and Chronic inflammatory diabetes mellitus pdf indonesia demyelinating polyneuropathy and diabetes
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