dexamethasone induced diabetes animal rat mice negative adverse side effect - Dexamethasone Administration in Mice Leads to ace inhibitors and statins adolescent type 1 diabetes Less Body Weight Gain Experimental animal models for diabetes and its related complicationsa In a recent comprehensive metabolomic study based on a single dose exposure to Dex in healthy human volunteers multiple metabolic changes predicted the side effects related to this exposure Bordag et al 2015 However this prediction could not be validated without observing the actual side effects which only can be done in an animal model Dexamethasoneassociated metabolic effects in male mice are partially In this study we evaluated the hypothesis that reactivation of MR via lowdose corticosterone addon can prevent dexamethasoneinduced metabolic side effects by performing studies in male C57Bl6J mice Materials and methods Animals Given that insulin resistance is a common side effect of dexamethasone 26 27 Synthetic glucocorticoids are clinically used to treat autoimmune and inflammatory disease Despite the high efficacy glucocorticoid treatments causes side effects such as obesity and insulin resistance in many patients iViai their pharmacological target the glucocorticoid receptor GR gl Dexamethasoneassociated metabolic effects in male mice are partially SingleDose Dexamethasone Induces WholeBody Insulin Resistance and DexamethasoneInduced Insulin Resistance Attenuation by Oral Sulfur The differences observed between the effects of acute dexamethasone treatment on the rat and DIO mouse insulin resistance models may be attributable to the diets provided to the animals In the present study mice were dosed with dexamethasone after being placed on a highfat diet for 8 wk whereas in the previous study rats were kept on a Effect of Dexamethasone on Glucose Tolerance and Fat Metabolism in a Metabolomics Based Profiling of Dexamethasone Side Effects in Rats Dexamethasone Dex is a synthetic glucocorticoid that has antiinflammatory and immunosuppressant effects and is used in with type 2 diabetes should you replace meals several conditions such as asthma and severe allergy Patients receiving Dex either at a high dose or for a long time might develop several side effects such as hyperglycemia STZinduced diabetic rats were injected with a rapidacting insulin 8 units IN 4 days after diabetes induction the rats killed 180 min later and heparinreleasable LPL activity determined in perfused hearts inset Heparinreleasable LPL activity was also determined before and after termination of the 3h euglycemichyperinsulinemic clamp Metabolomics Based Profiling of Dexamethasone Side Effects in Rats Animal models for induction of diabetes and its complications STZ induce diabetes rats mice and other animals like rabbit and guinea pigs through two ways depending on the dose At high dose STZ targets pancreatic β cells by its alkalyting property which is a normal function of the cytotoxic nitrosourea compounds 53 The frequency of diabetes mellitus is rising and diabetic rats and mice models are thought to be crucial for understanding the pathophysiology of human diabetes and its consequences Additionally the use of diabetic rat models is vital for researching and creating new medications to treat diabetes and its side effects The effects of V IV Ooctd were evaluated in a female Swiss mice model of insulin resistance induced by seven days of dexamethasone treatment in comparison with groups receiving metformin treatment Biological assays such as hematological TyG index hepatic lipids glycogen oxidative stress in the liver and oral glucose tolerance tests Dexamethasone induced hyperinsulinemia with concomitant low glucose levels independently of NRF2 Acute or chronic dexamethasone treatment did not affect NRF2 signaling All the aforementioned effects of dexamethasone were independent of gender Dexamethasoneinduced osteoporosis in male mice was independent 6 http sobatdiabet.org keturunan-diabetes of NRF2 Author Contributions
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