diabetes akumulasi sorbitol - Clinical Use of Sorbitol as a what is the difference between type 2 diabetes and type 1 Sweetening Agent in Diabetes Mellitus High glucose concentrations congruent to 50 mmoll impair the filterability of erythrocytes through 3 micron pores and the intracellular accumulation of sorbitol in poorly controlled outpatients is therefore unlikely to have a major adverse effect on erythrocyte rheology in diabetes mellitus Clinical Significance of Erythrocyte SorbitolBlood Glucose Ratios in Effects of hyperglycaemia and sorbitol accumulation on erythrocyte Sorbitol osmoregulation and the complications of diabetes Biochemistry Polyol Or Sorbitol Pathways StatPearls NCBI Bookshelf Sorbitol accumulation is altered in Type 1 insulindependent diabetes The use of sorbitol as a sweetening agent in diabetic foodsdiets has received substantial attention since its first recommendation for this purpose in 1929 In 1941 70 Ellis and Krantz observed that a single dose of 25 or 50 g of sorbitol does not elevate blood glucose levels in normal individuals 70 The polyol pathway has been implicated in the pathogenesis of diabetic complications To determine the activity of the polyol pathway the ratio of erythrocyte sorbitol to blood glucose which reflects aldose reductase activity was evaluated in 329 patients with type II noninsulindependent diabetes mellitus and in 100 nondiabetic agematched control subjects The sorbitol production rate calculated from K m and V max values showed a better correlation with the erythrocyte sorbitol level r 080 P 0005 and there was also a good correlation between the erythrocyte sorbitol level and the product of aldose reductase activity by plasma glucose level r 070 P 0005 We conclude that both The sorbitol or polyol pathway is a twostep metabolic pathway that converts glucose into fructose This pathway is thought to play a prominent role in explaining the pathogenesis of complications in patients with endstage diabetes In light of this this activity presents the biochemistry behind this pathway summarizes the individual reactions and their importance reviews the prevailing does the pinch method work for diabetes We compared sorbitol given alone and as part of a mixed meal to nine insulindependent diabetics IDDs during continuous subcutaneous insulin infusion CSII Blood glucose sorbitol and breath hydrogen methane were measured following six test meals Pure glucose sorbitol and lactulose a mixed meal alone and sweetened with sorbitol and Young RJ Ewing DJ Clarke BF A controlled trial of sorbinil an aldose reductase inhibitor in chronic painful diabetic neuropathy Diabetes 1983 Oct 32 10938942 Google Scholar Jaspan JB Towle VL Maselli R Herold K Clinical studies with an aldose reductase inhibitor in the autonomic and somatic neuropathies of diabetes Intracellular sorbitol accumulation has been implicated as an aetiological factor for many of the complications of diabetes mellitus Erythrocyte sorbitol is found in higher concentration in Type 1 insulindependent diabetic patients than in normal subjects When sorbitol accumulation is corrected for its immediate prescursor glucose sorbitolglucose ratio the polyol accumulation remains A palatable ice cream preparation in which sorbitol has been used as the sweetening agent in place of sucrose has been fed to 38 diabetic patients The slow absorption of sorbitol and its conversion to fructose and glycogen prior to its availability as glucose has led to consideration of this substance for use as an adjunct in diabetic diets In mild and moderately severe diabetic Sorbitol as a sweetener in the diet of insulindependent diabetes Some products of the sorbitol metabolic pathway of glucose were extracted from peripheral nerves and spinal cords of rats identified and measured Within a few days after a diabetic state was induced with streptozotocin glucose sorbitol and fructose in nerve and cord had risen sharply as blood glucose increased Effect of Blood Sugar Control on the Accumulation of Sorbitol and Suitability of sugar alcohols as antidiabetic supplements A review Crucial Role of Aldose Reductase Activity and masagi indonesia obat diabetes Plasma Glucose Level in
how does diabetes cause metabolic acidosis
gd hospital and diabetes institute
