diabetes and atherosclerosis pathophysiology - The link between diabetes and atherosclerosis obat diabetes merusak ginjal Lucia La Sala Journal of Diabetes JDB is an open access diabetes and metabolism journal devoted to diabetes research therapeutics and education Atherosclerosis Pathophysiology of insulin resistance hyperglycemia hyperlipidemia and inflammation Atherosclerosis is a chronic disease which only stands to become even more significant as life Lipidlowering in diabetes An update Atherosclerosis Diabetes and vascular disease pathophysiology clinical consequences The Diabetes MellitusAtherosclerosis Connection The Role of Lipid and A simplified scheme of the pathophysiological connection of diabetes mellitus and atherosclerosis Dyslipidemia hyperglycemia and insulin resistance result in a spectrum of physiological changes including the formation of atherogenic lowdensity lipoprotein LDL advanced glycation end products AGE and activation of proinflammatory signaling that impact different cell types of the Diabetes Mellitus to Accelerated Atherosclerosis Shared Cellular and Diabetes Mellitus Promotes the Development of Atherosclerosis The Role Clinical Update Cardiovascular Disease in Diabetes Mellitus Atherosclerotic cardiovascular disease ASCVD is accelerated in people with diabetes Dyslipidemia hyperglycemia oxidative stress and inflammation play a role via a variety of mechanisms operative in the artery wall In addition some unique features predispose people with type 1 diabetes to accelerated atherosclerosis Various organizations have created guidelines that provide advice Context Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus Despite the frequency and severity of disease proven medical therapy remains incompletely understood and underused Objective To review the epidemiology pathophysiology and medical and invasive treatment of atherosclerosis in patients with diabetes mellitus Atherosclerosis accounts for virtually 80 of all diabetesrelated mortality It is also a principal reason for hospitalization of patients with diabetes Diabetes profoundly affects the what is diabetes diet plan pathogenesis of atherosclerosis through various mechanisms Established cardiovascular risk factors are more prevalent in diabetic than in nondiabetic patients NLRP3 plays an important role in both diabetes and atherosclerosis While the diversity of its activation modes is one of the underlying causes of complex effects in the progression of diabetes and atherosclerosis it also provides many new insights for targeted interventions in metabolic diseases Atherosclerosis Pathophysiology of insulin resistance hyperglycemia Diabetes and Atherosclerosis Mechanisms and Management Diabetesrelated microvascular disease such as retinopathy and nephropathy are major causes of blindness and renal insufficiency 1 Based on this scenario a better understanding of the mechanisms underlying diabetic vascular disease is mandatory because it may provide novel approaches to prevent or delay the development of its complications Cardiovascular disease remains the principal cause of death and disability among patients with diabetes mellitus Diabetes mellitus exacerbates mechanisms underlying atherosclerosis and heart failure Unfortunately these mechanisms are not adequately modulated by therapeutic strategies focusing solely on optimal glycemic control with currently available drugs or approaches In the setting of Clinical relationships between diabetes and atherosclerosis are well established The majority of the clinical and experimental data regarding the onset of diabetes complications are associated with atherosclerosis suggesting that the impact of chronic hyperglycaemia might induce damage on vascular homeostasis mainly attributable to the endothelium function Diabetes is one of the critical independent risk factors for the progression of cardiovascular disease and the underlying mechanism regarding this association remains poorly understood Hence it is urgent to decipher the fundamental pathophysiology and consequently provide new insights into the id Diabetes and pengaruh kucing pada penderita diabetes atherosclerosis epidemiology pathophysiology and
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