diabetes and heart failure pathophysiology - Type 2 diabetes is one of american medical association guide to living with diabetes (epub|pdf|mobi) the most relevant risk factors for heart failure the prevalence of which is increasing worldwide The aim of the review is to highlight the current perspectives of the pathophysiology of heart failure as it pertains to type 2 diabetes This review summarizes the proposed mechanistic bases explaining the myocardial damage induced by diabetesrelated stressors and Type 2 Diabetes Mellitus and Heart Failure A Scientific Statement From The Pathophysiology of Cardiovascular Disease and Diabetes Beyond Among HF patients the prevalence of DM is 2 to 25 times higher than in the general population In the Korean Heart Failure KorHF registry from 1998 to 2003 the prevalence of DM was 31 In the Korean Acute Heart Failure Registry KorAHF from 2004 to 2009 36 had diabetes Diabetes mellitus predisposes affected individuals to a significant spectrum of cardiovascular complications one of the most debilitating in terms of prognosis is heart failure Indeed the increasing global prevalence of diabetes mellitus and an aging population has given rise to an epidemic of diabetes mellitusinduced heart failure Despite the significant research attention this Diastolic dysfunction interferes with the hearts ability to relax and fill with blood 50 Heart failure in a patient with diabetes may arise from myocardial damage resulting from an ischemic thrombotic event In this case endothelial dysfunctionoxidation and glycation of atherogenic lipids and the hypercoagulability of the blood are major Diabetes Cardiomyopathy and Heart Failure Endotext NCBI Bookshelf Epidemiology Pathophysiology Diagnosis and Treatment of Heart Failure Patients with diabetes mellitus have gt2 the risk for developing heart failure HF HF with reduced ejection fraction and HF with preserved ejection fraction Cardiovascular outcomes hospitalization and prognosis are worse for patients with diabetes mellitus relative to those without Beyond the structural and functional changes that characterize diabetic cardiomyopathy a complex Type 2 diabetes mellitus is a risk factor for incident heart failure and gambar manusia kena penyakit diabetes increases the risk of morbidity and mortality in patients with established disease Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies Recent clinical trials have demonstrated the shared pathophysiology Basic Mechanisms of Diabetic Heart Disease Heart failure in diabetes PMC National Center for Biotechnology Diabetes mellitus DM is a group of diseases characterised by metabolic disturbances with increasing prevalence worldwide Individuals with DM present several detrimental micro and macrovascular complications such as retinopathy nephropathy neuropathy atherosclerosis and coronary heart disease23 Accordingly efforts for early diagnosis and appropriate management are of ultimate Introduction Heart failure HF is the most common cardiovascular complication of diabetes mellitus DM 1 2This is not surprising since DM and HF share common pathogenetic factors Figure 1Heart dysfunction in the diabetic population may develop regardless of typical risk factors such as hypertension and coronary artery disease The increased incidence of heart failure in diabetic Heart failure in the diabetic population pathophysiology diagnosis Heart Failure in Type 2 Diabetes Mellitus Circulation Research Heart failure HF is an underappreciated complication of diabetes HF occurs in individuals with diabetes at higher rates even in the absence of other HF risk factors such as coronary artery disease and hypertension Comorbid ischemic heart disease and cardiovascular risk factors significantly contribute to the etiology of cardiomyopathy and HF in patients with diabetes In addition long Heart failure in type 2 diabetes current perspectives on screening 2 Diabetes mellitus DM impairs cardiac metabolic flexibility Heart disease remains the leading cause of death for both Type 1 and Type 2 diabetes mellitus T1DM and T2DM patients In diabetic patients the availability and the usage of substrates by the heart is drastically disturbed Fig 1Impaired insulin signaling causes both hyperglycemia and hyperlipidemia due to the decreased Diabetes Mellitus diabetes melitus dan tbc and Heart Failure PMC
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