diabetes and vascular - Diabetic retinopathy may be the most diabetes se bachne ke liye khana common microvascular complication of diabetes It is responsible for 10000 new cases of blindness every year in the United States alone 1 The risk of developing diabetic retinopathy or other microvascular complications of diabetes depends on both the duration and the severity of hyperglycemia Development of diabetic retinopathy in patients with type Vascular complications of diabetes pose a severe threat to human health Prevention and treatment protocols based on a single vascular complication are no longer suitable for the longterm Diabetes and vascular disease pathophysiology clinical consequences The vascular complications of diabetes are the most serious manifestations of the disease Atherosclerosis is the main reason for impaired life expectancy in patients with diabetes whereas diabetic nephropathy and retinopathy are the largest contributors to endstage renal disease and blindness respectively The most wellestablished clinical Epidemiological studies have documented that insulin resistance and diabetes not only constitute metabolic abnormalities but also predispose to hypertension vascular stiffness and associated cardiovascular disease Meanwhile excessive arterial stiffness and impaired vasorelaxation in turn contribute to worsening insulin resistance and the development of diabetes Molecular mechanisms Introduction Diabetes mellitus is not merely a disorder of carbohydrate metabolism but a cause of vascular disease affecting nearly all blood vessel types and sizes Indeed vascular complications are responsible for most of the morbidity hospitalizations and death that occur in patients with diabetes mellitus 1 Vascular Complications of Diabetes Circulation Research In addition to vascular disease diabetes itself can also cause lower limb neuropathy microvascular disease and changes in foot dynamics These factors work together with PAD to cause diabetic foot For patients diabetes diagnosis icd 10 ulkus diabetes can worsen the quality of life after PAD onset Studies have pointed out that compared with the general population DIABETIC CARDIOVASCULAR DISEASE getting to the heart of the matter PMC Diabetic vascular diseases molecular mechanisms and therapeutic Vascular diseases particularly atherosclerosis are major causes of disability and death in patients with diabetes mellitus Diabetes mellitus substantially increases the risk of developing coronary cerebrovascular and peripheral arterial disease The pathophysiology of vascular disease in diabetes involves abnormalities in endothelial Hypertension in Diabetes An Update of Basic Mechanisms and Clinical Diabetes and Vascular Disease Research Sage Journals The Impact of Diabetes on Vascular Disease Progress from the Diabetes and Vascular Disease Circulation AHAASA Journals MicroRNAs involved in diabetic vascular disease Schematic representation of microRNAs and their relative targets contributing to reduced vascular repair and hence diabetesrelated vascular dysfunction VEGF vascular endothelial growth factor IGF1 insulinlike growth factor1 ECs endothelial cells AGEs advanced glycation endproducts Microvascular and Macrovascular Complications of Diabetes The diabetic metabolic milieu predisposes to aggressive obstructive coronary artery disease that causes heart attacks heart failure and death Furthermore diabetes can be associated with heart failure independent of underlying coronary artery disease hypertension or valve abnormalities The pathogenesis of the vascular and myocardial Diabetes Vascular Disease Research is the first international peerreviewed journal to unite diabetes and vascular disease in a single title It mirrors the increasing recognition that diabetes and cardiovascular disease are a single entity in which diabetes and related disorders such as insulin resistance are directly linked with assaults on the vessel wall and the development of vascular Vascular complications of diabetes mechanisms jurnal klasifikasi diabetes melitus of injury and protective
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