diabetes animal models - Animal models of obesity and diabetes sembuh diabetes mellitus Nature Animal models are increasingly being used to elucidate the mechanisms underlying both Type 1 and Type 2 diabetes as well as to identify and refine novel treatments However a wide range of different animal models are currently in use The majority of these models are suited to addressing certain specific aspects of diabetes research but may The choice of animal model will depend on the study design Increasing understanding of different subsets of Type 1 and Type 2 diabetes would enable more appropriate animal models to be selected or developed as it is unlikely that one animal model or one treatment will fit the broad spectrum of disease in either Type 1 or Type 2 diabetes The pig is another large animal model used for translational studies in research on obesity and diabetes mellitus Obesity in pigs is routinely induced by highenergy highfat andor high The use of animal models in diabetes research PMC Experimental animal models for diabetes and its related complicationsa Acute and chronic animal models for the evaluation of antidiabetic Frontiers Animal models for type 1 and type 2 diabetes advantages Abstract Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure Animal models for diabetes Understanding the pathogenesis and finding NODmouse diabetes prone BB rats KDP rat LETL rat and LEWiddm rat are the widely used animal models of spontaneous diabetes for studying the autoimmune diabetes 28 Nonobese diabetic NOD mouse is one of the most regularly utilized models dieta para la diabetes mellitus for investigations of type 1 diabetes T1D Animal models for induction of diabetes and its complications Animal models are widely used for novel drug development for treatment of diabetes and its complications Various rodents like mice rats and hamster have found to be the suitable models for the purpose of research and they also help to find the pathogenesis of the disease 4 The majority of research on diabetes is conducted on animals Animal models for diabetes Understanding the pathogenesis and finding The most frequently used large animal models include pigs dogs and cats most diabetic cats have a disease entity similar to human type 2 diabetes mellitus whereas in most diabetic dogs the Mammalian models of diabetes mellitus with a focus on type 2 diabetes In animal models this deficiency in insulin production is achieved by a variety of different mechanisms ranging from chemical ablation of the beta cells to breeding rodents that spontaneously develop autoimmune diabetes Some of the most commonly used models of type 1 diabetes are outlined in Table 1 Animal models In general experimental diabetes mellitus is instigated in animals because animal models plays an effective role in understanding the pathogenesis of the disease Even though a number of in vitro and in silico studies are available and are improved in the last decades animal models still remains the effective one in understanding the complex etiology and multisystemic These animal models are discussed below and summarized in Table 1 Streptozotocin and Alloxan are the most frequently used agents to chemically induce T1DM in animals 53 Both diabetogenic agents are toxic to pancreatic islet β cells which can consequently induce hyperglycemia within a few days 22 Experimental animal models for diabetes diabetes tangan bengkak and its related complicationsa
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