diabetes complication ncbi - Diabetes

diabetes complication ncbi - Epidemiology of Diabetes and DiabetesRelated Complications what does diabetes do to your skin The traditional complications of diabetes mellitus are well known and continue to pose a considerable burden on millions of people living with diabetes mellitus However advances in the management of diabetes mellitus and consequently longer life expectancies have resulted in the emergence of evidence of the existence of a different set of Type 2 Diabetes StatPearls NCBI Bookshelf Approximately 40 of the total cost of diabetes in the United States is due directly to inpatient care for treatment of diabetes complications77 Several studies have estimated annual and cumulative economic costs of diabetes complications over time7879 These studies found that macrovascular disease mainly cardiovascular events and stroke Diabetes Diabetes mellitus DM is a chronic metabolic disorder characterized by persistent hyperglycemia It may be due to impaired insulin secretion resistance to peripheral actions of insulin or both According to the International Diabetes Federation IDF approximately 415 million adults between the ages of 20 to 79 years had diabetes mellitus in 20151 DM is proving to be a global public It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required but also for its major complications affecting both small and large blood vessels These complications occur in the majority of individuals with both type 1 and type 2 diabetes Among the most Diabetes mellitus is taken from the Greek word diabetes meaning siphon to pass through and the Latin word mellitus meaning sweet A review of the history shows that the term diabetes was first used by Apollonius of Memphis around 250 to 300 BC Ancient Greek Indian and Egyptian civilizations discovered the sweet nature of urine in this condition and hence the propagation of the word In 2015 approximately 50 million deaths were attributed to diabetes albeit in the same year more than 12 burning mouth diabetes of the global health expenditure was dedicated to coping with the disease and its complications Diabetes complications are common among patients with type 1 or type 2 diabetes but at the same time are responsible for significant Complications of Diabetes 2017 PMC PubMed Central PMC The burden and risks of emerging complications of diabetes PubMed Mechanisms of diabetic complications PubMed Diabetes and its Complications PMC PubMed Central PMC Dyslipidemia is also a common complication of diabetes Apolipoprotein M apoM as a novel apolipoprotein may be related to the development and progression of diabetes which need to further investigation Obstructive sleep apnea OSA is another common complication of diabetes and is an independent risk factor for cardiovascular disease CVD Global trends in diabetes complications a review of current PubMed New insights into diabetes mellitus and its complications a narrative More than 30 of the type 2 diabetes patients suffer from cardiovascular complications and nearly half of type 2 diabetes related deaths occur due to CVD CVD covers a plethora of dysfunctions in the cardiovascular system including atherosclerosis myocardial infarction heart failure and cardiomyopathy Emerging Targets in Type 2 Diabetes and Diabetic Complications In recent decades large increases in diabetes prevalence have been demonstrated in virtually all regions of the world The increase in the number of people with diabetes or with a longer duration of diabetes is likely to alter the disease profile in many populations around the globe particularly due to a higher incidence of diabetesspecific complications such as kidney failure and Lower extremity wounds are one of the most serious and prevalent complications of diabetes with a lifetime incidence of 1525 among patients with diabetes and associated with low healing and high amputation rates 20ref21 MMP9 recently emerged as a highimpact target to improve diabetic wound healing 2125 vidio diabetes Chang and coworkers showed

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