diabetes dan billirubin - Bilirubin as a Potential Causal Factor complications of diabetes mellitus pdf in Type 2 Diabetes Risk A Association between serum total bilirubin levels and the risk of type 2 Effect of bilirubin concentration on the risk of diabetic complications Keywords Bilirubin Unconjugated bilirubin Type 2 diabetes Diabetic retinopathy 1 Background Unconjugated bilirubin UCB also known as indirect bilirubin IBIL is one of the types of serum bilirubin and has long been known to have oxidative toxicity and neurotoxicity Bilirubin Diabetes Metabolic Syndrome and Obesity Clinical Evidence Negative associations between serum bilirubin concentrations and abnormal glucose tolerance tests were reported as early as 1996 Ko et al 1996 Since then numerous clinical studies evaluating the possible associations between serumplasma bilirubin levels and the Bilirubin has been regarded as a powerful endogenous antioxidant and anti inflammatory agent Thus it stands to reason that higher TBili levels may be protective against the autoimmune inflammationrelated pathology of type 1 diabetes and oxidative physiologic stress associated with development of type 2 diabetes High Total Bilirubin as a Protective Factor for Diabetes Mellitus An Bilirubin as a potential causal factor in type 2 diabetes risk a Indeed serum bilirubin has been consistently shown to be negatively correlated to cardiovascular diseases CVD as well as to CVDrelated diseases and risk factors such as arterial hypertension diabetes mellitus metabolic syndrome and obesity In addition the clinical data are strongly supported by evidence arising from both in vitro and Experimental and human studies show that elevated bilirubin levels are associated with decreased risk of type 2 diabetes T2D and diabetesrelated outcomes 16Bilirubin might antagonize oxidative stress by acting as an antioxidant and cytoprotectant which may have beneficial effects in diseases related to oxidative stress 710For example we have previously shown that elevated Type 2 diabetes in an foot infections diabetes endocrine disorder characterized by hyperglycemia resulting from variable degrees of insulin resistance and deficiency Chronic hyperglycemia can lead to multiorgan damage resulting in renal neurologic and cardiovascular complication The worldwide prevalence of adult T2DM is 9 in men and 79 in women In China the prevalence of T2DM and prediabetes is 116 and 50 The association between bilirubin levels and the incidence of The objective of this metaanalysis was to investigate the association between plasma bilirubin levels and the incidence of metabolic syndrome and diabetes mellitus across all populations Several databases were searched including PubMed Medline Scopus Web of Science and Embase Elsevier to identify relevant cohort studies All cohort studies that reported the risk ratio along with a Diabetes can affect many parts of the body and is associated with serious complications Oxidative stress is a major contributor in the pathogenesis of diabetic complications and bilirubin has The role of bilirubin in diabetes metabolic syndrome and Highnormal serum bilirubin is a useful indicator to assess the risk of Circulating bilirubin a natural antioxidant is associated with decreased risk of type 2 diabetes T2D but the nature of the relationship remains unknown We performed Mendelian randomization in a prospective cohort of 3381 participants free of diabetes at baseline age 2875 years women 526 We used rs6742078 located in the uridine The role of bilirubin in diabetes metabolic syndrome and Serum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies while the relation to type 2 diabetes T2D in the elderly remains unclear 15575 participants with 2532 diabetes cases serum bilirubin levels total direct and indirect increased in new onset diabetes and decreased Serum bilirubin levels and risk of type 2 bolehkah diabetes makan rambutan diabetes results from two
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