diabetes hepatic cell lines - Adipocyte inflammation is the primary driver diabetes wond of hepatic insulin The liver is a critical tissue for maintaining glucose fatty acid and cholesterol homeostasis However access to primary hepatocytes can be limiting Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes a comprehensive resource for in vitro studies of hepatic metabolism Am J Physiol Endocrinol Metab Suitability of hepatocyte cell lines HepG2 AML12 and THLE2 for Hyperglycemia induces key genetic and phenotypic changes in human liver Immortalized human hepatic cell lines for PubMed Central PMC Insulin signaling and glucose metabolism in different hepatoma cell Cell lines originating from hepatic tumours are immortal but also cells from healthy organs can be artificially immortalized with a variety of methods In general liver cell lines are often used for studies on xenobiotic metabolism and hepatotoxicity and the focus is drawn towards enzyme capacities In diabetes research the signalling Along these lines our model could readily be expanded to include gene editing and other iPSCderived cell types to study the effects of hepatic insulin resistance on metabolic disease progression HepG2 cells are a widely used human liver epithelial cell line and have been extensively used in studying different hepatic diseases and insults Diabetes 2015648278090 102337db141772 PMC free article Google Scholar 20 Warrier M Hinds TD Jr Ledford KJ Cash HA Patel PR Bowman TA et al Susceptibility to dietinduced These characteristics proved to be instrumental for modeling of MASLD using hepatic cell lines 242526 primary cells 16272829 and human induced pluripotent stem cell iPSCderived cells 3031 diabetes membutakan mata Over the years several human hepatic cell lines have been produced whether or The ubiquitous shortage of primary human hepatocytes has urged the scientific community to search for alternative cell sources such as immortalized hepatic cell lines Diabetes 200453105112 doi 102337diabetes531105 Our data in cell lines suggest that high blood glucose and lipids promote ADAM10 activation and proteolytic cleavage of gp130 potentiating sgp130 secretion from hepatic stellate cells along with IL6 In line with IL6 transsignaling playing a role in NAFLD pathobiology higher plasma sgp130 strongly correlated with liver stiffness and was Immortal hepatocyte cell lines are widely used to elucidate insulindependent signalling pathways and regulation of hepatic metabolism although the often tumorigenic origin might not represent the metabolic state of healthy hepatocytes We aimed to investigate if murine cell line AML12 and human ce Hepatoma cell lines are widely used to model the hepatocyte for insulin signaling and fatty liver disease However a direct comparison of insulin action in primary hepatocytes and in hepatoma Lipid and glucose metabolism in hepatocyte cell lines and PubMed Modeling and therapeutic targeting of inflammationinduced hepatic Increased hepatic gluconeogenesis and type 2 diabetes mellitus Suitability of hepatocyte cell lines HepG2 AML12 and THLE2 for GDF15 also regulates the energy balance by reducing food intake by binding to its cognate receptor glial cell linederived neurotrophic factor GDNF family receptor αlike αKetoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling Sci Adv 8 2022 Article eabn2879 IL6 TransSignaling Is Increased reverse your diabetes in Diabetes Impacted by
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