diabetes mellitus and alzheimer's disease - Background The impact of diabetes on alternative diabetes type 2 treatment the risk of Alzheimers disease remains uncertain This study aimed to explore this issue from multiple perspectives by using the Mendelian randomization MR approach Methods Instrumental variables for predicting six diabetic traits including insulin and blood glucose eight metabolic risk factors for diabetes including total cholesterol and blood The relationship between diabetes and the dementia risk a Type 2 diabetes mellitus and Alzheimers disease PMC The exact connection between Alzheimers disease AD and type 2 diabetes is still in debate However poorly controlled blood sugar may increase the risk of developing Alzheimers This relationship is so strong that some have called Alzheimers diabetes of the brain or type 3 diabetes T3D Type 2 Diabetes Mellitus and Alzheimers Disease Overlapping Keywords Type 2 Diabetes Mellitus Alzheimers disease Environment Air pollution Pesticides Introduction Type 2 diabetes mellitus T2DM and Alzheimers disease AD are both agerelated disorders diabetes tipo 2 causa impotÊncia A number of studies over the past two decades have suggested that T2DM patients are at an increased risk of AD What39s the relationship between diabetes and dementia Impact of diabetes mellitus on the risk of Alzheimers A 2013 metaanalysis by Kapil Gudala et al revealed that diabetic patients have a 73 higher risk of dementia compared to nondiabetics including a 56 increased risk of Alzheimers Disease AD Type 3 Diabetes and Its Role Implications in Alzheimers Disease Epidemiological and biological evidences support a link between type 2 diabetes mellitus DM2 and Alzheimers disease AD Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia One of the more intriguing hypotheses is that diabetes directly causes Alzheimer39s disease Indeed Alzheimer39s disease has even been called type 3 diabetes because of shared molecular and cellular features atun y diabetes among diabetes and Alzheimer39s
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