diabetes mellitus type 2 journal review - Diabetes mellitus DM is a chronic bersihin luka diabetes metabolic disorder characterized by persistent hyperglycemia It may be due to impaired insulin secretion resistance to peripheral actions of insulin or both According to the International Diabetes Federation IDF approximately 415 million adults between the ages of 20 to 79 years had diabetes mellitus in 20151 DM is proving to be a global public Type 2 Diabetes Mellitus A Review of MultiTarget Drugs PMC Type 2 diabetes mellitus in adults pathogenesis prevention and Review Article Diabetes mellitus From molecular mechanism to Type 2 Diabetes StatPearls NCBI Bookshelf Type 2 diabetes mellitus T2DM is an expanding global health problem closely linked to the epidemic of obesity Individuals with T2DM are at high risk for both microvascular complications Pathophysiology of type 2 diabetes mellitus T2DM The adipose tissue is an endocrine organ that can secrete several hormones and cytokines namely TNFα IL6 resistin which are able to induce a chronic inflammation state and insulinresistanceFurthermore in obese patients with metabolic syndrome is more common to observe low adiponectin levels and a leptinresistance state Type 2 diabetes accounts for nearly 90 of the approximately 537 million cases of diabetes worldwide The number affected is increasing rapidly with alarming trends in children and young adults up to age 40 years Early detection and proactive management are crucial for prevention and mitigation of microvascular and macrovascular complications and mortality burden Access to novel therapies Nowadays diabetes mellitus has emerged as a significant global public health concern with a remarkable increase in its prevalence This review article focuses on the definition of diabetes mellitus and its classification into different types including type 1 diabetes idiopathic and fulminant type 2 diabetes gestational diabetes hybrid forms slowly evolving immunemediated diabetes New insights diabetes foot complications into diabetes mellitus and its complications a narrative Association of risk factors with type 2 diabetes A systematic review Type 2 diabetes mellitus may go undiagnosed at the early stage because it progresses rather slowly and asymptomatically sometimes with mild hyperglycemia Sociodemographic and lifestylerelated risk factors for identifying vulnerable groups for type 2 diabetes a narrative review with emphasis on data from Europe BMC Endocr Disord 20 Flowchart of the selection of relevant studies 31 Serum uric acid Serum uric acid a common component of urine generated by the metabolic breakdown of purines have been associated with insulin resistance and type 2 diabetes High serum uric acid level in an individual leads to 1 nitricoxide mediated vasoconstriction contraction of blood vessels leading to impaired glucose uptake in Type 2 diabetes mellitus Nature Reviews Disease Primers Diabetes mellitus Classification mediators and complications A gate Wang H Li X Tang Z et al Cardiovascular Outcomes Post Percutaneous Coronary Intervention in Patients with Obstructive Sleep Apnea and Type 2 Diabetes Mellitus A Systematic Review and MetaAnalysis Diabetes Ther 2020111795806 101007s13300020008706 PMC free article Google Scholar 47 Advances in the management of type 2 diabetes in adults Type 2 diabetes is a chronic and progressive cardiometabolic disorder that affects more than 10 of adults worldwide and is a major cause of morbidity mortality disability and high costs Over the past decade the pattern of management of diabetes has shifted from a predominantly glucose centric approach focused on lowering levels of haemoglobin A1c HbA1c to a directed complications Type 2 diabetes T2D is a disease characterized by heterogeneously progressive loss of islet β cell insulin secretion usually occurring after the presence of insulin resistance IR and it is Type menaikkan berat badan diabetes 2 diabetes The Lancet
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