diabetes metformin add-on choices - Comparison of the efficacy of antidiabetic diabetes mellitus cartoon images medications as addon to Introduction Metformin is the recommended initial treatment in type 2 diabetes mellitus T2DM but when this does not give adequate glucose control the choice of which secondline drug to use is uncertain as none have been found to have a better overall glycaemic response In this realworld study dipeptidyl peptidase 4 inhibitors DPP4i Options for addon therapy include sulfonylureas thiazolidines dipeptidyl peptidase4 DPP4 inhibitors sodium glucose cotransporter 2 SGLT2 inhibitors glucagonlike peptide 1 GLP1 agonists and insulin Providers have frequently prescribed a sulfonylurea after metformin because such agents are low in cost have longterm safety data The importance of metformin in the treatment of type 2 diabetes is well established In joint guidelines from the American Diabetes Association and the European Association for the Study of Diabetes it is recommended as the firstline pharmacological therapyThe positioning of this drug within the treatment algorithm is not the result of chance but rather of the numerous advantages Abstract In Brief For patients with type 2 diabetes who require addon therapy to metformin plus basal insulin GLP1 receptor agonists may be a favorable option because they effectively manage postprandial glucose reduce body weight and have an overall favorable safety profile compared to other agents Given the wide range of treatment combinations available for type 2 diabetes management Initial management of hyperglycemia in adults with type 2 diabetes Trends in addon medications following metformin monotherapy for type 2 Choice of The Addon Therapy to Metformin in Type 2 Diabetes Patients Therapeutic Options for the Management of Postprandial Glucose in Although metformin is generally universally recommended as a firstline pharmacologic therapy for most people living with type 2 diabetes secondline and thirdline choices can require a tailored approach diabetes waarden omrekenen to achieve optimal blood glucose and glycated hemoglobin levels The secondline or thirdline antihyperglycemic medications can either Background Metformin is recommended as a firstline drug in the guidelines of the treatment for type 2 diabetes mellitus However highquality evidence from clinical trials directly comparing the degree of hypoglycemic effect of combination therapy of metformin and a hypoglycemic agent with a different mechanism of action with that of monotherapy of a hypoglycemic drug is lacking We aimed to The results of these studies can be used to make better choices for our patients with type 2 diabetes Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus What Next After Metformin in Type 2 Diabetes Selecting the Right Drug Recommendations for Practical Use of Metformin a Central PURLs Need an addon to metformin Consider this Glycemic management Target glycated hemoglobin A1C levels in patients with type 2 diabetes should be tailored to the individual balancing the anticipated reduction in microvascular complications over time with the immediate risks of hypoglycemia and other adverse effects of therapy A reasonable goal of therapy is an A1C value of 7 Management of Blood Glucose with Noninsulin Therapies in Type 2 AAFP Type 2 Diabetes Therapies A STEPS Approach AAFP It has been estimated that metformin monotherapy failure occurs with a mean rate of 17 per year Based on data collected in this noninterventional study metformin was initiated in less than 1 year after diagnosis of type 2 diabetes with the first addon therapy started in more than 3 years after metformin Metformin is either weight neutral or induces moderate weight loss and it reduces mortality and cardiovascular events in patients with type 2 diabetes 11 Even if diabetes effect on hormone patients advance to insulin
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