diabetes octet - In his 2008 Banting lecture to vitamin a for diabetes the American Diabetes Association 68th Scientific Sessions Prof Ralph DeFronzo proposed an ominous octet of eight factors that contributed to the pathophysiology of type 2 diabetes decreased insulin secretion decreased incretin effect increased lipolysis increased glucose reabsorption decreased glucose Recognition that multiple pathophysiological disturbances comprise the ominous octet has provided new insight into novel approaches for the treatment of patients with type 2 diabetes In the following sections we will review antidiabetic agents that have shown promise for the treatment of type 2 diabetes Is It Time to Change the Type 2 Diabetes Treatment Paradigm Realworld diabetes prevention from theory to practice It is well established that type 2 diabetes T2D is a complex metaboliccardiovascular disorder with at least eight distinct pathophysiological disturbances referred to as the Ominous Octet Hyperglycemia is a manifestation of these eight pathophysiological abnormalities Both the CT and TT genotypes predict type kidney cancer and diabetes 2 diabetes in multiple ethnic groups In both the Malmo and Botnia studies presence of either the CT or TT genotype was associated with a significant reduction in the diabetesfree survival time with odds ratios of 158 and 161 respectively The Ominous Octet of Diabetes The everevolving pathophysiology of diabetes mellitus From the triumvirate to the Ominous Octet and now the Egregious Eleven The mechanism of action of various medications in diabetes care will be reviewed The current classification system presents challenges to the diagnosis and treatment of patients with diabetes mellitus DM in part due to its conflicting and confounding definitions of type 1 DM type 2 DM and latent autoimmune diabetes of adults LADA From the Triumvirate to the Ominous Octet A New Paradigm for Ominous Octet Diabetes MyEndoConsult The Time Is Right for a New Classification System for Novel Agents for the Treatment of diabetes alert dog Type 2 Diabetes PMC
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