diabetes pca - Epidemiological studies suggest a lower prostate how i know if i have diabetes cancer PCa incidence in patients with type 2 diabetes 12 However the cancer survival in the case of coexisting diabetes is clearly reduced Both diabetes and PCa rank among the most frequent diseases in males worldwide with an enormous impact on morbidity and mortality The relationship between diabetes prostatespecific antigen screening Prostate cancer PCa and type 2 diabetes mellitus T2DM are prevalent conditions that often occur concomitantly However many aspects of the impact of T2DM particularly the duration of T2DM and antidiabetic medications on PCa risk are poorly understood To assess the association of duration of T2DM and antidiabetic medication with PCa risk we designed a matched casecontrol study Blood glucose glucose balance and diseasespecific survival after Type 2 diabetes mellitus DM is a metabolic disease that has been positively associated with an increased risk of cancers of some organs such as pancreas liver biliary tract endometrium kidney colon and esophagus 1 4 In contrast the association between DM and prostate cancer PCa may be inverse Type II diabetes has been linked with increased risk of many cancer types possibly through hyperglycemia and hyperinsulinemia For prostate cancer PCa the findings are more controversial Specifically diabetes was associated with decreased risk of highgrade PCa in normalweight men but increased risk in obese men OR 035 vs 138 In the REDUCE trial when all men underwent A green teatriggered genetic control system for treating diabetes in TO THE EDITOR Diabetes mellitus DM and prostate cancer PCa are two diseases that pose a serious threat to global health DM primarily affects blood sugar regulation while PCa is one of the most common cancers in men12With an aging population structure and changes in lifestyle the incidence of bolehkah penderita diabetes makan pisang ambon both diseases is on the rise Diabetes Mellitus and Risk of Prostate Cancer in the Health Purpose Men with diabetes have been found to have a reduced risk of prostate cancer PCa potentially due to detection bias from lower prostatespecific antigen PSA levels or inhibition of tumor growth Understanding if lower PCa rates are due to a lower risk of the disease or a detection bias from PSA testing can help inform the benefits and harms from prostate cancer screening Abstract Background Some studies have directed towards an association between diabetes mellitus DM and prostate cancer PCa however this specific relationship remains inconclusive In recent years Mendelian randomization MR has become a widely used analytical method for inferring epidemiological causes Diabetes and prostate cancer risk in the REDUCE trial Diabetes and the Prostate Elevated Fasting Glucose Insulin Resistance Core Tip Diabetes mellitus DM is a chronic metabolic disease caused by many factors Prostate cancer PCa is a common malignant tumor in men and is the second leading cause of cancer death The Mendelian randomization MR method uses genetic variation as an instrumental variable to detect and quantify causal relationships which can avoid the impact of confounding factors on the accuracy Association of type 2 diabetes mellitus and antidiabetic medication Diabetes mellitus and prostate cancer risk A mendelian randomization Diabetes mellitus and prostate cancer risk A mendelian PubMed To achieve oral infusion of PCA or green tea to treat diabetes we further developed an improved PCA ON switch 20 Two stably isogenic cell clones HEK PCAON2SEAPP2AmINS and HEK PCAON2shGLP1P2ASEAP were further selected for cellbased diabetes therapy in mice and monkeys To assess the safety of diabetes therapy in monkeys blood Unraveling the biological link between why does diabetes cause hyperkalemia diabetes mellitus and prostate
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