diabetes thrombosis pathophysiology - Diabetesrelated microvascular disease such as retinopathy what are the 2 types of diabetes called and nephropathy are major causes of blindness and renal insufficiency 1 Based on this scenario a better understanding of the mechanisms underlying diabetic vascular disease is mandatory because it may provide novel approaches to prevent or delay the development of its complications Summary In patients with diabetes atherosclerosis is the main reason for impaired life expectancy and diabetic nephropathy and retinopathy are the largest contributors to endstage renal disease and blindness respectively An improved therapeutic approach to combat diabetic vascular complications might include blocking mechanisms of injury Diabetes mellitus DM and its complications pose a serious threat to human health and have become a global public health issue 12 Over 90 of patients with diabetes have type 2 DM T2DM 34 Is Diabetes Mellitus an Independent Risk Factor for Venous This review will provide an overview of what is currently known about mechanisms linking poor glycaemic control with increased thrombotic risk The leading causes of death in people with diabetes are strokes and cardiovascular disease Significant morbidity is associated with an increased risk of thrombosis resulting in myocardial infarction ischaemic stroke and peripheral vascular disease Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis Diabetes mellitus substantially increases the risk of developing coronary cerebrovascular and peripheral arterial disease The pathophysiology of vascular disease in diabetes involves abnormalities in endothelial vascular smooth muscle cell and platelet function The metabolic abnormalities that characterize diabetes such as hyperglycemia Diabetes mellitus is a reported risk factor for VTE 13 and pulmonary embolism PE 4 and a metaanalysis estimated a 14fold increased risk of VTE for persons with diabetes 5 However analyses of data from the Nurses Health Study and from maple syrup for diabetes the Heart and Estrogenprogestin Replacement Study HERS failed to find an association between diabetes and PE or VTE respectively 6 7 This could be Diabetes mellitus and thrombosis PubMed Diabetes Mellitus and Ischemic Diseases Arteriosclerosis Thrombosis Diabetes Mellitus and Cardiovascular Disease Arteriosclerosis Vascular complications of diabetes mechanisms of injury and protective Thrombosis and Vascular Inflammation in Diabetes Mechanisms and In patients with diabetes mellitus the ability of ischemic tissue to synchronize the molecular and cellular events leading to restoration of tissue perfusion in response to the atherosclerotic occlusion of a patent artery is markedly impaired As a consequence adverse tissue remodeling and the extent of ischemic injury are intensified leading to increased morbidity and mortality Growing Atherothrombosis is the leading cause of morbidity and mortality in patients with diabetes mellitus Several mechanisms contribute to the diabetic prothrombotic state including endothelial dysfunction coagulative activation and platelet hyperreactivity In particular diabetic platelets are characterised by dysregulation of several signaling Diabetes and vascular disease pathophysiology clinical consequences Pathophysiology Both extensive vascular pathology and an enhanced thrombotic environment contribute to premature vascular occlusive events and poor clinical outcome in patients with diabetes Mechanistic pathways for increased thrombosis risk in diabetes The metabolic changes in diabetes are associated with increased platelet activation Diabetes and Vascular Disease Circulation AHAASA Journals Cardiovascular disease CVD remains a leading cause of morbidity and mortality in type 1 diabetes mellitus and type 2 diabetes mellitus T2D 13 Beyond the inherent increase in mortality in diabetic subjects when diabetes mellitus is combined with manifestations of CVD such as myocardial infarction or stroke the mortality rate is nearly doubled leading to an estimated reduction in Diabetic vascular diseases diabetes dental treatment jurnal molecular mechanisms and therapeutic
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