distal symmetric polyneuropathy diabetes - 1 Introduction Distal symmetrical polyneuropathy DSPN daftar pustaka ekawati 2912 gula darah diabetes is a serious complication of diabetes with a lifetime prevalence of more than 50 in people with diabetes a population globally estimated at half a billion and expected to rise to 700 million by 2045 DSPN also still commonly referred to as diabetic peripheral neuropathy is defined by the American Diabetes Association as Mechanisms and management of diabetic painful distal symmetrical Diagnostic and Therapeutic Advances Distal Symmetric Polyneuropathy Distal symmetric polyneuropathy in diabetes a progressive disorder Pathogenesis of Distal Symmetrical Polyneuropathy in Diabetes Diabetes prediabetes alcohol use B12 deficiency inherited conditions chemotherapy chronic kidney disease and paraproteinemia are the most common causes of distal symmetric polyneuropathy Even after appropriate testing the cause of distal symmetric polyneuropathy is unknown idiopathic in 2427 Distal symmetrical polyneuropathy DSPN is a serious complication of diabetes associated with significant disability and mortality Although more than 50 of people with diabetes develop DSPN its pathogenesis is still relatively unknown This lack of understanding has limited the development of no CHRONIC SENSORIMOTOR NEUROPATHY OR DISTAL SYMMETRIC POLYNEUROPATY DPN The most common form of neuropathy in diabetes is a distal symmetrical polyneuropathy It occurs in both type 1 and type 2 DM with similar frequency and may already be present at the time of diagnosis of type 2 DM Sensory symptoms include numbness dead feeling Distal Symmetric Polyneuropathy A Review Neurology JAMA Network Pathogenesis of Distal Symmetrical Polyneuropathy in Diabetes Diabetic Neuropathy A Position Statement by the American Diabetes Distal symmetric polyneuropathy A definition for clinical research Although a number of the diabetic neuropathies may result in diabetes diare painful symptomatology this review focuses on the most common chronic sensorimotor distal symmetrical polyneuropathy DSPN It is estimated that 1520 of diabetic patients may have painful DSPN but not all of these will require therap In its typical form distal axonal polyneuropathy is characterized by a bilateral symmetrical sensory disturbance beginning distally in the toes and feet and over time ascending proximally to include the upper limbs the result is a classic stockingglove presentation for both symptoms and signs More intensive glucose control substantially reduces the incidence of distal symmetric polyneuropathy in patients with type 1 diabetes but not in those with type 2 diabetes Conclusions and Relevance The opportunity exists to improve guidelineconcordant testing in patients with distal symmetric polyneuropathy Moreover the role of Diabetic peripheral neuropathy which is the most prevalent and rigorously studied type of distal symmetric polyneuropathy was the target disorder in most studies There is a relative lack of highquality evidence for other varieties of distal symmetric polyneuropathy Abstract Distal symmetric polyneuropathy DSPN is the most common chronic complication of diabetes mellitus The pathogenesis of DSPN is not fully elucidated but it is certainly multifactorial in nature and attributable to metabolic and microvessel disorders related to chronic hyperglycemia diabetes duration and several cardiovascular risk factors Advances in the diagnosis and management of diabetic distal symmetric Diabetic Neuropathies Endotext NCBI Bookshelf Among the various forms of diabetic neuropathy distal symmetric polyneuropathy DSPN and diabetic autonomic neuropathies particularly cardiovascular autonomic neuropathy CAN are by far the most studied 14 There are several atypical forms of diabetic diabetes di totok neuropathy as well 14
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