dna repair and diabetes - Compromised DNA repair is responsible for can diabetes make you fat diabetesassociated fibrosis Polymorphisms in DNA repair genes can affect the function of encoded proteins and alter the DNA repair capacity the 726 Ala ADPRT allele a gene encoding the enzyme poly ADPribose polymerase1 PARP1 was significantly susceptible to increased risk of T2D 69 109 In diabetes due to DNA strand breaks Elevated markers of DNA damage and senescence are associated with the A growing body of data supports a new model of βcell dysfunction where DNA damage response triggers βcell dedifferentiation and death 711Patients treated with wholebody or abdominal radiation have an increased incidence of diabetes potentially due to radiationinduced DNA damage in islets Human and mouse βcells from subjects with T2D have DNA breaks and oxidized DNA 810 Reduced expression of OXPHOS and DNA damage genes is linked to The Transcription Factor YY1 Is Essential for Normal DNA Repair and Mechanisms underlying the pathophysiology of type 2 diabetes From risk DNA damage can cause mutation which plays key roles in carcinogenesis Thus DNA damage is possibly a biological link between diabetes and cancer Apart from optimizing glycemic control future cancer prevention in diabetic patients may target at inhibiting DNA damage using alternative drugs like antioxidants Go to Evidence for DNA Damage as a Biological Link Between Diabetes and DNA damage may be associated with type 2 diabetes mellitus T2DM and its complications mainly through oxidative stress Little is known about DNA repair disturbances potentially contributing to the overall extent of DNA damage in T2DM which in turn may be linked with genomic instability resulting in cancer Little is known about DNA repair disturbances potentially contributing to DNA damage in diabetes In the present bio simapro luka diabetes study we determined a potential mechanism by which ROS result in 8oxodG accumulation and explored the role of tuberin phosphorylation and OGG1 in the kidney cortex of rats with type 1 diabetes Oxidative Stress DNA Damage and DNA Repair in Female Patients with Diabetes mellitus type 2 T2DM is associated with oxidative stress which in turn can lead to DNA damage The aim of the present study was to analyze oxidative stress DNA damage and DNA repair in regard to hyperglycemic state and diabetes duration The role of DNA damage in diabetic complications Nature Mechanism of Oxidative DNA Damage in Diabetes PMC DNA damage and repair in type 2 diabetes mellitus PubMed Here we show that experimental type 1 and type 2 diabetes impairs DNA repair leading to senescence inflammatory phenotypes and ultimately fibrosis Carbohydrates were found to trigger this cascade by decreasing the NAD NADH ratio and NHEJrepair in vitro and in diabetes mouse models Restoring DNA repair by nuclear overexpression of One of the many reasons for impaired DNA repair in diabetes mellitus is the hyperglycaemiainduced perturbed NAD NADH equilibrium 3This perturbation reduces the availability of free PARP1 While clinical studies have shown an association between markers of DNA damage and diabetic complications their relation to the cause of complications and their progression remains unclear 8 9 18 22 24 27 2934 There are several data pointing to the importance of the DNA repair system in human diabetes but also its crucial role in the BER is considered to be a key pathway for recognition and repair of diabetesinduced persistent ROSinduced DNA damage 28 Although the role of OXPHOSborn ROS and DNA damage diabetes harndrang wie oft in the risk of
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