dream trial diabetes - Clinical Implications of the DREAM Trial diabetes mellitus diagnosis classification and pathophysiology harrison page Medscape Education Effect of Ramipril on the Incidence of Diabetes The DREAM trial The Lancet he Diabetes REduction Assessment with ramipril and rosiglitazone Medication DREAM study reported in September 2006 This international multicentre randomised double blind placebo controlled 2by2 factorial prospective threeyear study examined the effect of rosiglitazone 8 mgday andor ramipril 15 mgday to prevent progression to type 2 diabetes in 5269 adults with impaired The DREAM trial explored the incidence of diabetes in one trial with a 22 factorial design and therefore four treatment groups placebo rosiglitazone only ramipril only and both drugs combined The DREAM Diabetes REduction Assessment with ramipril and rosiglitazone Medication Trial Investigators The DREAM trial and related studies will determine if ramipril or rosiglitazone reduces the number of cases of diabetes and atherosclerosis and will identify novel risk factors for diabetes design and recruitment characteristics of a large simple international trial of diabetes prevention the DREAM trial Diabetologia 2004 Sep479 Effects of Ramipril and Rosiglitazone on Cardiovascular and Renal The DREAM trial The Lancet The Diabetes REduction Assessment with ramipril and rosiglitazone Medication DREAM trial randomly allocated people with impaired fasting glucose IFG andor impaired glucose tolerance IGT without known cardiovascular disease CVD or significant renal disease to the ACE inhibitor ramipril or placebo and the thiazolidinedione rosiglitazone or placebo according to a 2 2 factorial design Diet and lifestyle changes are typically recommended for the prevention of diabetes in people with profiles similar to those of the participants in our study 34 The DREAM trial did not show that It seems noteworthy and not just coincidence that the extent of hazard reduction for diabetes in individuals at risk in the rosiglitazone group of the DREAM usia rentan diabetes trial 1 is almost identical to that seen in two large studies of diabetes prevention by lifestyle change 23 The risk of overt type 2 diabetes or death within 3 years was reduced by 60 Type 2 diabetes prevention is a major public health issue The Diabetes REduction Assessment with ramipril and rosiglitazone Medication DREAM trial showed that the newonset diabetes rate in people with impaired glucose tolerance IGT andor impaired fasting glucose IFG can be slowed substantially 60 relative to placebo by the thiazolidinedione rosiglitazone but not by the ACE Aimshypothesis The Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication DREAM trial reported that 3 years of therapy with rosiglitazone reduced the primary outcome of diabetes or death by 60 Here we investigated whether an effect on diabetes prevention persists more than 15 years after therapy has been discontinued Rationale design and recruitment characteristics of a large simple Longterm effect of rosiglitazone andor ramipril on the PubMed Effect of rosiglitazone on the frequency of diabetes in patients with DREAM a diabetes prevention study Deane Conlon 2006 SAGE Journals Incidence of Diabetes Following Ramipril or Rosiglitazone Withdrawal The DREAM trial prospectively evaluated the effect of reducing the frequency of type 2 diabetes in adults N 5269 with IGT IFG or both The trial was a doubleblind placebocontrolled multicenter trial 191 sites in 21 countries A detailed description of the design of the DREAM trial has been published previously 14 Briefly 24 592 people aged 30 years or more were assessed for eligibility with a 75 g oral glucose tolerance test between July 2001 and August 2003 at 191 sites in 21 countries Inclusion criteria included either impaired fasting glucose fasting plasma glucose concentration ciri yang merupakan pertanda gejala diabetes insipidus ditunjukkan oleh nomor 61 mmolL and 70
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