end organ damage diabetes - Target organ damage and incident type asia bebas diabetes 2 diabetes mellitus Diabetic kidney disease DKD is a serious microvascular complication that affects approximately 40 of individuals with diabetes Presently the leading cause of endstage kidney disease ESKD worldwide DKD affects 700 million people and it disproportionately affects those who are socially disadvantaged Diabetes mellitus DM is a chronic metabolic disease characterized by elevated blood glucose caused by deficiency or resistance to insulin Joslin 1946Chronic hyperglycemia can lead to multiple organ injury thereby causing various complications such as diabetic retinopathy DR diabetic kidney disease DKD and diabetic cardiovascular disorders Zheng et al 2018 It is well understood that the burden of diabetes is attributed to chronic progressive damage in major endorgans but it is underappreciated that the most superficial and transparent organ End Organ Damage from Diabetes Concept Id C3830315 Endothelial dysfunction in vascular complications of diabetes End organ damage Wikipedia CCI values range from 0 to a theoretical maximum of 33 depending on the presence of certain diseases with assigned scores Diabetes belongs in the CCI scoring one point when endorgan damage is absent and two points when retinopathy neuropathy or nephropathy is present 25 Fall assessment The vascular complications of diabetes are the most serious manifestations of the disease Atherosclerosis is the main reason for impaired life expectancy in patients with diabetes whereas diabetic nephropathy and retinopathy are the largest contributors to endstage renal disease and blindness respectively The most wellestablished clinical A Rare and Unique Complication of Uncontrolled Type 2 Diabetes Information Medication For Type 2 Diabetes How Are Your Body Organs Affected by Diabetes Verywell Health Abstract Diabetesassociated sequelae lead to a considerable reduction in the quality of life and conspicuous increase in mortality Subsequent damage becomes manifest in terms of macroangiopathy as coronary heart disease peripheral arterial occlusive disease and cerebrovascular insufficiency Moreover there is high risk of diabetic The early detection and severity of typical end organ damage and secondary diseases are key determinants of cardiovascular prognosis in patients suffering from arterial hypertension 2 The classic manifestations of hypertensive end organ damage include the following vascular and hemorrhagic stroke retinopathy coronary heart disease INTRODUCTION The skeleton is increasingly recognized as a site of endorgan damage in diabetes The effects of diabetes on bone are complex and an area of active investigation While most studies demonstrate that fracture risk is increased in both type 1 and type 2 diabetes bone mineral density BMD as measured by dualenergy xray Epub 2013 May 10 doi 101900RDS2013106 PMID 24172695 Free PMC Article Irreparable damage to multiple organssystems which is the result of chronic complications of diabetes The affected organssystems include the cardiovascular system kidneys eyes nervous system joints and feet Mainly two main types of diabetes exist type 1 and type 2 Type 1 diabetes develops at early stages of life due to an autoimmune disorder where the cells of the immune system attack the insulin producing β cells of the pancreas Type 2 diabetes however develops later in life due to systemic dysfunctions in metabolic homeostasis A systematic review on the impact of diabetes mellitus on the Background Recent analyses in a registry of hypertensive patients suggested that xerostomÍa en diabetes preceding left ventricular LV hypertrophy LVH andor carotid atherosclerosis are associated with incident type 2 diabetes independent of confounders We assess the relation between prevalent cardiorenal target organ damage TOD and subsequent incident type 2 diabetes in a populationbased study with high End Organ Damage In Hypertension PMC PubMed Central PMC Bone disease in diabetes mellitus UpToDate Abstract Diabetes mellitus is a heterogeneous group of disorders characterized by hyperglycemia due to an absolute or relative deficit in insulin production or action The chronic hyperglycemia of diabetes mellitus is associated with end organ damage dysfunction and failure including the retina kidney nervous system heart and blood vessels Emerging Targets in Type 2 Diabetes and Diabetic Complications View All Heart Kidneys Brain Lungs Pancreas Diabetes can affect many major organs including your heart eyes kidneys and brain When the disease isn39t wellcontrolled it can lead to many serious comorbidities which are conditions that occur alongside diabetes General aspects of diabetes mellitus PubMed End organ damage is severe impairment of major body organs due to systemic disease Commonly this is referred to in diabetes high blood pressure or states of low blood pressure or low blood volume 1 This can present as a heart attack or heart failure pulmonary edema neurologic deficits including a stroke or acute kidney failure Prediction of complications of type 2 Diabetes A Machine The longterm outlook of patients diagnosed with diabetic myonecrosis is poor as the disease indicates severe endorgan damage from the progression of the underlying diabetes mellitus Diabetes myonecrosis resolves over 55 weeks to 13 weeks depending on the level of therapy initiated with antiplatelet agents and antiinflammatory drugs the This study developed and validated prediction models to estimate the 10year risk of cardiovascular events and mortality in patients with type 2 diabetes and obesity who underwent metabolic surgery or usual care The study also created userfriendly webbased and smartphone applications of Individualized Diabetes Complications IDC Risk Scores for clinical use A large body of scientific evidence supports the importance of controlling hyperglycemia hypertension hypercholesterolemia body weight and promoting smoking cessation in order to reduce end organ damage associated with diabetes Discover Helpful Information And A Downloadable Doctor Discussion Guide Get Tips For Talking To Your Loved Ones About Type 2 Diabetes Heart Disease Diabetic complications Micro and macroangiopathic endorgan Diabetic Nephropathy Update on Pillars of Therapy Slowing Clinical evidence of diabetes mellitus endorgan damage as The Effects of Type 2 Diabetes Mellitus on Organ Metabolism Predicting 10Year Risk of EndOrgan Complications of Type 2 An update on chronic complications of diabetes mellitus from In addition in experimental models of cardiovascular endorgan damage associated with diabetes ANG 17 has been shown to act as an antiinflammatory agent It regulates the expression of VCAM1 induced by ANG II by reducing the nuclear translocation of NFκB in ECs Vascular complications of diabetes mechanisms of injury and Abstract Metabolic abnormalities such as dyslipidemia hyperinsulinemia or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus T2DM The field of immunometabolism implies a bidirectional link between the immune system and metabolism in which inflammation plays an diabetes and leg pain and weakness treatment essential role in the
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