etiology diabetes mellitus type 1 weight loss filetype pdf - PDF PATHOPHYSIOLOGY OF DIABETES MELLITUS Academic diabetes gala Journals In this chapter we review the etiology and pathogenesis of Type 1 diabetes mellitus T1DM with particular emphasis on the most common immune mediated form Whereas Type 2 diabetes T2DM appears to be an increasing price paid for worldwide societal affluence there is also evidence worldwide of a rising tide of T1DM The increase in understanding of the pathogenesis of T1DM has made it The genetics of type 1 diabetes is reviewed in depth in Chapter 12 Genetics of Type 1 Diabetes and only briefly summarized in the following section In this chapter infectious dietary and other environmental factors are reviewed in detail as well as potential geneenvironment interactions in type 1 diabetes etiology FIGURE 112 PDF Diabetes management 1 disease types symptoms and diagnosis emap PDF Type 1 Diabetes Mellitus ResearchGate Types of Diabetes Mellitus Type 1 Diabetes Mellitus It is the most aggressive type and causes rapid weight loss It occurs in childhood and adolescence It causes autoimmune destruction of the β cells of the islets of Langerhans Autoantibodies against β cells against insulin against tissue glutamic decarboxylase and tyrosine phosphatase PDF Understanding Diabetes Mellitus Causes Symptoms and Complications PDF Chapter 11 Risk Factors for Type 1 Diabetes National Institute of Type 1 Diabetes Mellitus Pathophysiology and etiology Result of pancreatic beta cell destruction GAD GADA islet antigen2 IA2A T1D type 1 diabetes zinc transporter 8 ZnT8A Long AE et al Diabetes 201261683686 Autoimmune Basis for Type 1 Diabetes 7 Type 1 diabetes represents around 10 of all cases of diabetes affecting approximately 20 million people worldwide American Diabetes Association 2001 Although type 1 diabetes affects all age groups the majority of individuals are diagnosed either at around the age of 4 to 5 bolehkah diabetes makan lele years or in their teens and early adulthood Blood et al 1975 Table 1 Type 1 diabetes mellitus susceptibility loci Locus Chromosome Markers Genes IDDM 1 6p21312132 IDDMHLA HLA PSMB8 TAP2 IDDM 2 11p155 5VINSVNTR TH INS IDDM 3 15q262 D15S107 IDDM 4 11q121132 FGF3 D11S1917 MDU1 ZFM1 RT6 ICE CD3 LRP5 LRP5 IDDM 5 6q251 ESR a046Xa9 MnSOD IDDM 6 18q122211 D18S487 D18S64 JK BCL2 In type 1 diabetes beta cell destruction may take place over several years but symptoms of the disease usually develop over a short period of time Type 1 diabetes typically occurs in children and young adults though it can appear at any age In the past type 1 diabetes was called juvenile diabetes or insulindependent diabetes mellitus 5 Describe the development of type 1 diabetes mellitus Type 1 diabetes develops in stages starting with the appearance of isletcell antibodies followed by progressive loss of betacell mass and function Type 1 diabetes is often diagnosed clinically when there has been a loss of at least 80 of betacell mass Fig 11 depicts the events A classic autoimmune disease type 1 diabetes is characterised by the progressive destruction of insulinproducing beta cells of the pancreas Genetics influences individual susceptibility to type 1 diabetes and around 10 of people with type 1 diabetes have a parent sibling or child with the condition Ferrannini et al 2010 Type 1 Diabetes Mellitus Etiology Presentation and Management PDF Diabetes Mellitus Classification Etiology and Pathogenesis PDF Pathophysiology of Type 1 Diabetes Type 1 Diabetes Mellitus PDF Causes of Diabetes Type 1 diabetes mellitus T1DM is a chronic lifelong disorder of glucose homeostasis characterized by autoimmune destruction of the insulinproducing pancreatic bcell leading progressively to Etiology and Pathogenesis of Diabetes what to drink with diabetes Mellitus in Children and
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