exosome mesenchymal diabetes type 2 mice - Human mesenchymal stemstromal cell basedtherapy in sweet smelling stool diabetes diabetes mellitus Mesenchymal stem cell exosomes MSCExos secretion can be divided into three miR132 from MSCderived exosomes in cognitively impaired mice can target the regulation of GTPaseactivating protein RASA1 and increase the Phan T Wang W Srikanth VK Type 2 diabetes mellitus brain atrophy and cognitive decline in older people a Diabetes mellitus DM a chronic metabolic disease poses a significant global health challenge with current treatments often fail to prevent the longterm disease complications Mesenchymal stemstromal cells MSCs are adult progenitors able to repair injured tissues exhibiting regenerative effects and immunoregulatory and antiinflammatory responses so they have been emerged as a Exosomes are nanosized extracellular vesicles EVs that show great promise in tissue regeneration and injury repair as mesenchymal stem cell MSC MSC has been shown to alleviate diabetes mellitus DM in both animal models and clinical trials In this study we aimed to investigate whether exosomes from human umbilical cord MSC hucMSCex have a therapeutic effect on type 2 DM T2DM We STZ treatmentinduced diabetes in mice a Schwarcz E Korsgren O le Blanc K Preserved βcell function in type 1 diabetes by mesenchymal stromal cells Diabetes 2015642587592 doi 102337db140656 Shi H Yin S et al Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing Exosomes as biomarkers and therapy in type 2 diabetes mellitus and Background The depletion of β cell mass is widely recognized as a significant contributor to the progression of type 2 diabetes mellitus T2DM Exosomes derived from mesenchymal stem cells MSCEXOs hold promise as cellfree therapies for treating T2DM However the precise effects and mechanisms through which MSCEXO affects β cell function remain incompletely understood and the limited Exosomes Secreted by Umbilical Cord BloodDerived Mesenchymal Stem Cell PEGylated βCellTargeting Exosomes from Mesenchymal Stem Cells Improve The roles of mesenchymal stem cellderived exosomes in diabetes penyuluhan diabetes melitus Mesenchymal Stem CellDerived Exosomes A Novel Approach to Diabetes Exosomes are nanosized extracellular vesicles EVs that show great promise in tissue regeneration and injury repair as mesenchymal stem cell MSC MSC has been shown to alleviate diabetes mellitus DM in both animal models and clinical trials In this study we aimed to investigate whether exosom Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes 42 Mesenchymal stem cellderived exosomes and type 2 diabetes mellitus and insulin resistance T2DM which accounts for 90 of patients with diabetes is primarily caused by peripheral insulin resistance pancreatic βcells mass loss and βcells dysfunction Glucose transporter 4 GLUT4 is the major glucose transporter in adipose and 1 Introduction Type 2 diabetes mellitus T2DM is a chronic metabolic disorder characterized by high blood glucose levels resulting from insulin resistance and impaired insulin secretion International Diabetes Federation reveals that the global prevalence of type 2 diabetes mellitus among adults was estimated to be 5366 million 105 in 2021 and this number will rise to 7832 million Type 2 diabetes mellitus T2DM is one of the most prevalent metabolic disorders worldwide More recent work by Wen et al identified that mice with diabetes had reduced expression of exosomes at large by the tubular Mesenchymal stem cellderived exosomes carry MicroRNA125a to protect against diabetic nephropathy by targeting histone Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Exosomes secreted by mesenchymal stem cells HucMSCexos were intravenously injected into mice with type 2 diabetes induced by HFD and STZ Yin S Ji C Zhang X Zhang B Wu P Shi Y Mao F Yan Y Xu W Qian H Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and Mesenchymal stem cellderived exosomes a promising vector in treatment Human Mesenchymal Stem Cell Derived Exosomes diabetes type 1 symptomen kind Alleviate Type 2 Diabetes
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