fat diet nicotinamide streptozotocin diabetes type 2 - A practical guide for induction of buah duku diabetes type2 diabetes in rat This NASTZ animal model as a platform for the testing of numerous antidiabetic and renoprotective materials is also discussed In comparison with other type 2 diabetic animal models such as highfatdietSTZ models and genetically engineered rodent models the NASTZ model is nonobese and is less timeconsuming and less expensive to create Several studies have reported that rats fed a highfat diet develop insulin resistance but not overt hyperglycemia or diabetes Tanaka et al 2007 Storlien et al 1986It was recently reported that rats fed a highfat diet and treated with lowdose streptozotocin can serve as an alternative animal model for type 2 diabetes because of their impaired insulin secretion glucose intolerance Chemical structures of nicotinamide and streptozotocin A nicotinamide B streptozotocin2 Mechanisms Underlying NASTZ Diabetes Induction Masiello P et al initially developed this nonobese type 2 diabetes in rats in 1998 Since then this model has been widely used to test a variety of antidiabetic materials for their beneficial effects on diabetes and diabetic complications The NicotinamideStreptozotocin Rodent Model of Type 2 Diabetes Renal Effects of antidiabetic drugs in highfat diet and streptozotocin One example of a type 2 diabetes animal model is the highfat dietfed streptozotocin HFDSTZtreated rat model The present review first summarizes the current understanding of the metabolic profile and pathology involved in the different stages of the type 2 diabetes disease progression in humans Second the known characteristics of the Modeling type 2 diabetes in rats using high fat diet and streptozotocin This review article highlights a widely used rodent model of nonobese type 2 diabetes induced by nicotinamide NA and streptozotocin STZ In comparison with the highfatdiet HFDSTZinduced type 2 diabetes animal models 25262728 and genetically engineered diabetic animal models such as dbdb mice Similarly in a study by Islam and Choi the diabetes at 50 highfat diet in combination with low dose STZ model was identified as a better model of type 2 diabetes than an alternative chemicallyinduced model that utilised an injection of nicotinamide prior to administration of STZ We found it was essential to fast the rats prior to STZ injection as The NicotinamideStreptozotocin Rodent Model of Type 2 Diabetes Renal Modeling type 2 diabetes in rats using high fat diet and streptozotocin Effects of antidiabetic drugs in highfat diet and streptozotocin Cardiac metabolism in a new rat model of type 2 diabetes using highfat Repeated administration of sitagliptin and rosiglitazone also improved hyperglycemia and insulin resistance These results demonstrate that a highfat diet combined with nicotinamide and streptozotocin injection induces a diabetic mouse model that replicates the metabolic characteristics of human type 2 diabetes The Characterization of HighFat Diet and Multiple LowDose Type2 diabetes T2D which used to be referred to adultonset or noninsulindependent diabetes accounts for over 9095 of all diabetes T2D is a complex metabolic disorder essentially characterized by alterations in lipid metabolism insulin resistance and pancreatic βcell dysfunction 2Obesity is the most common risk factor for the development of T2D 3 this may lead to elevated This might happen in decompensated phase of type 2 diabetes Highfat diet has been extensively used to develop insulin resistance 57 Therefore highfat diet combined with multiple low dose of STZ might develop a suitable type 2 diabetes animal model which presents not only insulin resistance but also insulin deficiency The NicotinamideStreptozotocin Rodent Model of Type 2 Diabetes MDPI One example of a type 2 diabetes animal model is the highfat dietfed streptozotocin HFDSTZtreated rat model The present review first summarizes the current understanding of the metabolic profile and pathology involved in the different stages of the type 2 diabetes disease progression in humans Second diabetes minum madu manis the known characteristics of
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