gen tcf7l2 pada diabetes - Association of TCF7L2 Variants in Type what happens in diabetes 2 Diabetes Mellitus with The Role of TCF7L2 in Type 2 Diabetes ResearchGate TCF7L2 the most important type 2 diabetes gene At the start of 2006 transcription factor7like 2 TCF7L2 was revealed as an unexpected suspect for a type 2 diabetes gene by the DECODE group in Iceland 6 This gene had initially drawn attention during followup research on a small linkage signal on chromosome 10 but it turned out See the article TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet βCells in volume 58 on page 894 Type 2 diabetes is associated with impaired insulin secretion Both 1st and 2ndphase insulin secretion are reduced but the effect is particularly pronounced for the 1st phase The processes culminating in impaired The Role of TCF7L2 in Type 2 Diabetes The increase in TCF7L2 expression with increasing numbers of T alleles was not due to diabetes per se as it was also seen in the nondiabetic individuals CC 33 04 CT 22 07 TT 46 09 P 002 Expression of TCF7L2 in human islets was lowest in carriers of HapA intermediate in HapAB carriers and highest in HapB carriers P The Role of TCF7L2 in Type 2 Diabetes PMC PubMed Central PMC Type 2 Diabetes Susceptibility Gene TCF7L2 and Its Role in βCell Type 2 Diabetes Susceptibility Gene TCF7L2 and Its Role in βCell Varian TCF7L2 berada dala m ekson 110 dan 11 pada masingmasing domain dan menunjukkan bahwa gen TCF7L2 memiliki hubungan erat dengan TCF7L2 pada Penderita Diabetes Tipe II di Wilayah Mechanisms by which common variants in the TCF7L2 gene increase risk of Abstract TCF7L2 is the most potent locus for type 2 diabetes T2D risk and the first locus to have been robustly reported by genomic linkage studies TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway apakah penderita diabetes boleh makan sate kambing This gene has highly conserved sequence regions that correspond to functional domains Type 2 Diabetes Mellitus T2DM is a chronic metabolic condition involving various genetic and environmental factors leading to impaired insulin secretion resulting in hyperglycemia The transcription factor 7like 2 TCF7L2 gene is an element of Type 2 Diabetes Mellitus and TCF7L2 Medscape Prime suspect the TCF7L2 gene and type 2 diabetes risk The Role of TCF7L2 in Type 2 Diabetes PubMed The human TCF7L2 gene was mapped to chromosome 10q253 and initially sequenced in colorectal cancer CRC cell lines TCF7L2 has 18 exons which present a complex splicing pattern in different tissues This gene has highly conserved sequence regions that correspond to functional domains The βcatenin binding domain corresponds to exon 1 and the HMG box binding domain corresponds to exons TCF7L2 was discovered as a type 2 diabetes susceptibility gene after a strong linkage signal was mapped to chromosome 10q in a MexicanAmerican population This region was later finemapped in the Icelandic population and confirmed in US and Danish cohorts where the risk locus was found to be located in intron 3 of the TCF7L2 gene TCF7L2 the susceptibility gene with the largest effect on disease susceptibility discovered to date was identified pregenomewide association by Grant et al in 2006 with rapid replication of its consequence on diabetes susceptibility in multiple populations 5 9 TCF7L2 was a positional candidate gene that mapped to a region of genetic linkage to type 2 diabetes in the Icelandic Structure of the TCF7L2 gene Localization of at risk intron 4 5 and 8 SNPs Modified from Duval et al T2D TCF7L2 is the most potent locus for T2D risk and the first locus to have been robustly reported by genomic linkage studies and genomewide association studies deCODE genetics initially detected linkage to T2D in the Icelandic population on dapus jurnal diabetes mellitusmenurut suastika k et al 2011 a chromosome 10 locus
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