genetic marker iin diabetes mellitus type 2 pdf - Diabetes is a group of metabolic apakah statin induced diabetes diseases characterized by hyperglycemia resulting from defects in insulin secretion insulin action or both The chronic hyperglycemia of diabetes is associated with longterm damage dysfunction and failure of differentorgans especially the eyes kidneys nerves heart and blood vessels Regardless of whether genetic predictors become useful markers of disease onset or of subtypes in clinical practice the identification of genetic variants associated with type 2 diabetes illustrates pathogenic mechanisms that may be targeted by future therapies Main body We reviewed the studies that explored markertrait association with type 2 diabetes mellitus globally with emphasis on India Globally single nucleotide polymorphisms SNPs rs7903146 of Transcription Factor 7like 2 TCF7L2 gene was common though there were alleles that were unique to specific populations Biomarkers for type 2 diabetes PMC PubMed Central PMC Type 2 diabetes T2D is the result of interaction between environmental factors and a strong hereditary component We review the heritability of T2D as well as the history of genetic and genomic research in this area Genetics of type 2 diabetes PMC PubMed Central PMC ABSTRACT Hyperglycemia of type 2 diabetes mellitus T2DM results from a complex interplay of genetic and environmental factors that influence a number of intermediate traits eg gcell mass insulin secretion insulin action fat distribution obesity Pathogenic variants in actionable MODY genes are associated with type 2 diabetes Article 12 October 2020 Introduction Diabetes is a metabolic disorder characterized primarily by chronic Epigenetics of the Pathogenesis and Complications of Type 2 A metaanalysis of genomewide association studies of type 2 diabetes T2D identifies more than 600 T2Dassociated loci integrating physiological trait and singlecell chromatin Genetic markers of type 2 diabetes Progress in genomewide Type 2 diabetes T2D has become a leading public health challenge worldwide To date a total of 83 susceptibility loci for T2D have been identified by genomewide association studies GWAS Genetics of type 2 diabetes mellitus in Indian and Global Endothelial Dysfunction in Type 2 Diabetes Mellitus PMC Type 2 diabetes is thought to result from a combination of environmental behavioral and genetic factors with the heritability of type 2 diabetes estimated to be in the range of 25 to 72 based on family and twin studies Common genetic variants and pathways in diabetes and Nature Genetic Determinants of Type 2 Diabetes Endocrine Society Epigenetics of type 2 diabetes mellitus T2DM has widened our knowledge of various aspects of the disease The aim of this review is to summarize the important epigenetic changes implicated in the disease risks pathogenesis complications and the evolution of therapeutics in our current understanding of T2DM Genetics of Type 2 Diabetes Review In Diabetes in America 3rd edition Bethesda MD National Institute of Diabetes and Digestive and Kidney Diseases US 2018 Aug CHAPTER 14 Authors Jose C Florez 1 Miriam S Udler 2 Robert L Hanson 3 Book Editors Catherine C Cowie 1 Genetics of Type 2 Diabetes PubMed Type 2 diabetes mellitus T2DM is a heterogeneous condition that is related to both defective insulin secretion and peripheral insulin resistance Beta cells are the major organ for secreting insulin hence it is important to maintain an adequate betacell mass in response to various changes Genetics of Type 2 Diabetes Past Present is type two diabetes insulin dependent and Future MDPI GENETICS OF TYPE 2 DIABETES Genetic drivers of heterogeneity in type 2 diabetes Nature Genetics of type 2 diabetes mellitus in Indian and Global Genetic architecture of oral glucosestimulated insulin release provides biological insights into type 2 diabetes aetiology A L Madsen S BonàsGuarch S Gheibi R Prasad J Type 2 diabetes mellitus T2DM is a heterogeneous condition that is related to both defective insulin secretion and peripheral insulin resistance Beta cells are the major organ for secreting insulin hence it is important to maintain an adequate betacell mass in response to various changes The endothelial dysfunction ED is an imbalance in the production of vasodilator factors eg NO prostacyclin PGI 2 endothelial derived hyperpolarizing factor EDHF and vasoconstricting factors eg ET1 AngII and prostaglandin PGH2 When this balance is disrupted it predisposes the vasculature towards prothrombotic and pro Type 2 diabetes mellitus pathogenesis and genetic diagnosis Diagnosis and Classification of Diabetes Mellitus PMC Genetics of type 2 diabetes mellitus Diabetes Research and Genetics of Type 2 Diabetes Diabetes in America NCBI In this review there is a major focus on risk factors and genetic and nongenetic biomarkers for the risk of T2D identified especially in large prospective populationbased studies and studies testing causality of the biomarkers for T2D in Mendelian randomization studies Genomic insights into the causes of type 2 diabetes Effects of Probiotic Supplementation on Inflammatory Markers Download PDF Summary Genomewide association studies have implicated around 250 genomic regions in predisposition to type 2 diabetes with evidence for causal variants and genes emerging for several of these regions The genetics of type 2 diabetes A review Early research aimed at identifying genetic determinants of diabetes complications relied on familial linkage analysis suited to strongeffect loci candidate gene studies prone to false Genetic architecture of oral glucosestimulated insulin Both types of diabetes show a disposition to run in families which is a strong indication of a genetic cause for the diseases However the aetiology underlying types 1 and 2 is quite different indicating that different genes are likely to be involved in the two types of diabetes mellitus The SNP rs7903146 of the TCF7L2 gene is the most significant genetic marker associated with type 2 diabetes risk in all the ethnicities This gene is a transcription factor that influences the transcription of several genes thereby exerting a large variety of functions within the cell Type 2 diabetes mellitus pathogenesis and genetic diagnosis Genetics of Type 2 Diabetes Past Present and Future by Markku Laakso 12 and Lilian Fernandes Silva 1 Institute of Clinical Medicine Internal Medicine University of Eastern Finland 70210 Kuopio Finland 2 Department of Medicine Kuopio University Hospital 70210 Kuopio Finland Author to whom correspondence should be addressed Genetics of diabetes mellitus and diabetes complications Nature Genetics of type 2 diabetes mellitus Maciej T Malecki mmaleckicmujkrakowpl Download PDF Abstract The clinical picture of type 2 diabetes mellitus T2DM is formed by impairment in insulin secretion and resistance to insulin action Type 2 diabetes mellitus T2DM is one of the most common endocrine and metabolic diseases and is characterized by impaired pancreatic islet β cell function and insulin resistance in insulin target tissues Gurung et al 2020 diabetes spierpijn benen Arora et al 2021
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