genetic type 2 diabetes - Excerpt Type 2 diabetes is thought bebas diabetes cara alami dan natural to result from a combination of environmental behavioral and genetic factors with the heritability of type 2 diabetes estimated to be in the range of 25 to 72 based on family and twin studies Since early 2007 genomewide association studies GWAS have led to an explosion of data for the genetics of Type 2 diabetes T2D is a multifactorial heritable syndrome characterized by dysregulated glucose homeostasis that results from impaired insulin secretion and insulin resistance Genetic association studies have successfully identified hundreds of T2D risk loci implicating many genes in disease pathogenesis Genetics of Type 2 Diabetes Implications from LargeScale Studies Keywords Type 2 diabetes Genetics TCF7L2 Genomewide association studies Heritability Core tip We review the history and the current state of knowledge regarding the genetic component of type 2 diabetes risk Genes like TCF7L2 that have been replicated in multiple studies are discussed in detail The significance of these findings is Abstract Type 2 diabetes T2D is a heterogeneous disease that develops through diverse pathophysiological processes 1 2 and molecular mechanisms that are often specific to cell type 3 4 Here Type 2 diabetes has a stronger link to family history and lineage than type 1 and studies of twins have shown that genetics play a very strong role in the development of type 2 diabetes Race can also play a role Yet it also depends on environmental factors Lifestyle also influences the development of type 2 diabetes Type 2 diabetes can be inherited but environmental factors also play a role Learn about the gene mutations linked to diabetes how to reduce your risk through lifestyle changes and when to get genetic testing dokter tan diabetes Since early 2007 the establishment of international consortia and biobanks has catalyzed the performance of largescale genomic studies These efforts have driven an explosion in the discovery of genetic variation associated with type 2 diabetes Most studies have involved genetic data captured using genotyping arrays populated by common single nucleotide polymorphisms SNPs although a Genetics of type 2 diabetes PMC PubMed Central PMC Genetics of Type 2 Diabetes Diabetes in America NCBI Bookshelf Genetic drivers of heterogeneity in type 2 diabetes Nature Type 2 diabetes developed in 2201 117 of these subjects during a median followup period of 235 years The addition of specific genetic information to clinical factors only slightly improved the prediction of future diabetes with an increase in the area under the curve AUC from 074 to 075 P 10 4 The majority of genetic variations associated with type 2 diabetes are thought to act by subtly changing the amount timing and location of gene activity expression These changes in expression affect genes involved in many aspects of type 2 diabetes including the development and function of beta cells in the pancreas the release and Genetics of Diabetes American Diabetes Association Type 2 diabetes MedlinePlus Genetics Is Type 2 Diabetes Genetic Environmental Factors and More Healthline Genetic Factors in Type 2 Diabetes The Genetic Landscape of Diabetes Genetics of Type 2 Diabetes PubMed Genetic Architecture of Type 2 Diabetes Recent Progress and Clinical For type 2 diabetes one such genetic risk is the gene that encodes PPARγ peroxisome proliferator activated receptor gamma Variants of this gene are among the first to be identified as causing a broad impact on the risk of mie instan boleh untuk diabetes developing type 2 diabetes
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