genezen diabetes type 2 - Abstract Type 2 diabetes T2D is diabetes mielitus a heterogeneous disease that develops through diverse pathophysiological processes 1 2 and molecular mechanisms that are often specific to cell type 3 4 Here Genetics of Type 2 Diabetes PubMed Genomewide association analyses identify 143 risk variants and Since early 2007 the establishment of international consortia and biobanks has catalyzed the performance of largescale genomic studies These efforts have driven an explosion in the discovery of genetic variation associated with type 2 diabetes Most studies have involved genetic data captured using genotyping arrays populated by common single nucleotide polymorphisms SNPs although a Genetics of type 2 diabetes PMC PubMed Central PMC Genetics of type 2 diabetes revealed in unprecedented detail Type 2 diabetes T2D is the result of interaction between environmental factors and a strong hereditary component We review the heritability of T2D as well as the history of genetic and genomic research in this area Very few T2D risk genes were identified using candidate gene and linkagebased studies but the advent of genomewide Genetics of Type 2 Diabetes Diabetes in America NCBI Bookshelf The prevalence of type 2 diabetes in youth has increased substantially yet the genetic underpinnings remain largely unexplored To identify genetic variants predisposing to youthonset type 2 diabetes we formed ProDiGY a multiethnic collaboration of three studies TODAY SEARCH and T2DGENES with 3006 youth case subjects with type 2 diabetes mean age 151 29 years and 6061 Excerpt Type 2 diabetes is thought to result from a combination of environmental behavioral and genetic factors with the heritability of type 2 diabetes estimated to be in the range of 25 to 72 based on family and twin studies Since early 2007 genomewide association studies GWAS have led to an diabetes melitus terjadi karena explosion of data for the genetics of Sequencing data from two largescale studies show that most of the genetic variation influencing the risk of type 2 diabetes involves common alleles and is found in regions previously identified The Play of Genes and Nongenetic Factors on Type 2 Diabetes The First GenomeWide Association Study for Type 2 Diabetes in Youth Genomic insights into the causes of type 2 diabetes Genetic drivers of heterogeneity in type 2 diabetes Nature Genomewide association studies have implicated around 250 genomic regions in predisposition to type 2 diabetes with evidence for causal variants and genes emerging for several of these regions Understanding of the underlying mechanisms including the interplay between βcell failure insulin sensitivity appetite regulation and adipose storage has been facilitated by the integration of Genomewide linkage scans have proved that some genes are associated with Type 2 diabetes on specific chromosomes such as 4q 12q and 22q in AA 6p in EA 2p in AI and 13q in African American 75 3p at marker D3S2406 in Mexicans Americans 76 and 2p and 13p of Chinese 77 increase the risk of developing the disease Type 2 diabetes T2D is a common disease with a worldwide prevalence that increased rapidly from 47 in 1980 to 85 in 2014 1It is primarily caused by insulin resistance failure of the bodys Type 2 diabetes is a global health concern with approximately ten percent of the worlds population diagnosed with the disease or likely to develop it in their lifetime Previous studies into the genetics of diabetes risk have identified over 80 areas in the human genome associated with type 2 diabetes however it remains unknown exactly how The genetic architecture of factor that causes diabetes type 2 diabetes Nature
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