gestational diabetes glucose transport - Gestational Diabetes Mellitus Pregnancy is a soal diabetes mellitus state characterized by profound metabolic and physiological changes to support fetal development and growth As an adaptation in healthy pregnancy maternal insulin sensitivity and insulinmediated glucose consumption in peripheral tissues including skeletal muscle and adipose tissue declines The placenta secretes hormones such as estrogens Gestational diabetes mellitus GDM is a serious pregnancy complication in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation The aforementioned increase in placental transport of glucose amino acids and fatty acids stimulate the fetuss endogenous production of insulin and insulinlike Placental Expression of Glucose and Zinc Transporters in Women with Placental glucose transport in gestational diabetes mellitus Other complications of gestational diabetes mellitus include neonatal hypoglycemia and maternal hypertensive disorders Furthermore hyperglycemia during pregnancy is associated with obesity and diabetes mellitus5 as well as gestational diabetes mellitus6 in the offspring Placental transfer of glucose is mediated by facilitated The Human Placenta in Gestational Diabetes Mellitus Maternal obesity during pregnancy is rising and is associated with increased risk of developing gestational diabetes mellitus GDM defined as glucose intolerance first diagnosed in pregnancy 1 Fetal growth is determined by the maternal nutrient supply and placental nutrient transfer capacity This will only have an effect if maternal glucose concentrations are high above postprandial glucose levels 1011 because of the high capacity of the transplacental glucose transport system Changes in placental amino acid transporters if at all are not associated with maternal diabetes but rather with elevated fetal weight However Placental Glucose Transport in GDM Alterations in placental glucose transport are reported to occur in GDM reviewed in 31 48 49 Table 2Namely an increase in GLUT1 expression and activity in the BM of the STB was found how does diabetes affect cholesterol by Gaither et al in women with GDM treated with diet alone or with diet and insulin therapyDespite all women having an adequate glycemic control at term the Placental Nutrient Transport in Gestational Diabetic Pregnancies Abstract While efficient glucose transport is essential for all cells in the case of the human placenta glucose transport requirements are twofold provision of glucose for the growing fetus in addition to the supply of glucose required the changing metabolic needs of the placenta itself The rapidly evolving environment of placental cells Human placental glucose transport in fetoplacental growth and Placental glucose transport in gestational diabetes mellitus Impact of Gestational Diabetes Mellitus in the MaternaltoFetal INTRODUCTION Depending on the region of the world race and ethnic origin the estimated prevalence of gestational diabetes mellitus GDM and type 1 pregestational diabetes mellitus PGDM among pregnant women is 58129 and 016024 respectively 1 2 3 Furthermore studies performed over the past few decades consistently demonstrate an upward trend in the prevalence of both Placental Nutrient Transport in Gestational Diabetic Pregnancies BackgroundObjectives Gestational diabetes GDM is a metabolic disorder with altered glucose levels diagnosed in pregnant women The pathogenesis of GDM is not fully known but it is thought to be caused by impaired insulin production and insulin resistance induced by diabetogenic factors The placenta may play an important role in the Placental expression of glucose transporters GLUT1 GLUT3 GLUT8 and The Pathophysiology of Gestational Diabetes Mellitus PMC Results Gestational diabetes mellitus was not associated with alterations in placental glucose transport Separate analysis of 6 patients in the gestational diabetes mellitus group with largeforgestationalage babies did not affect these results Conclusion These findings are consistent with the hypothesis that obat diabetes gliquidone the sensitivity of placental
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