glycated albumin and diabetes mellitus - Glycated albumin in nonDM exhibits a klinik diabetes dharma moderate diagnostic accuracy Further research on the diagnostic accuracy of GA for GDM and combinational measurements of GA and other assays is suggested Glycated albumin as a biomarker for diagnosis of diabetes mellitus A systematic review and metaanalysis World J Clin Cases 2021 Nov 69319520 Scope of review This review gives a background of and discusses the potential clinical utility of glycated albumin GA in diabetes Major conclusions GA is a ketoamine formed via a nonenzymatic glycation reaction of serum albumin and it reflects mean glycemia over two to three weeks GA can be used for patients with anemia or Keywords Diabetes mellitus glycated albumin glycated proteins INTRODUCTION Diabetes mellitus DM is a chronic metabolic disease caused by diminished or absent secretion of insulin or even by reduced tissue sensitivity to insulin 12 Presently DM is a worldwide epidemic and a great challenge to health care systems everywhere Role of Glycated Proteins in the Diagnosis and Management of Diabetes Objectives Guidelines recommend the diagnosis of diabetes should be based on either plasma glucose or glycated hemoglobin HbA 1C findings However lately studies have advocated glycated albumin GA as a useful alternative to HbA 1c We conducted a systematic review and metaanalysis to determine the overall diagnostic accuracy of GA for the diagnosis of diabetes Content We searched for Glycated albumin as a biomarker for diagnosis of diabetes mellitus A Glycated albumin from biochemistry and laboratory medicine Springer Glycated Albumin for the Diagnosis of Diabetes in US Adults This review summarizes current knowledge about glycated albumin We review the changes induced by glycation on the properties of albumin the pathological implications of high glycated albumin levels glycated albumin quantification methods and the use of glycated albumin as a complementary biomarker for diabetes mellitus diagnosis and monitoring and for dealing with longterm complications Glycated albumin a potential diabetes type 1 symptoms child biomarker in diabetes PMC Glycated albumin as a diagnostic tool in diabetes An alternative or an Keywords Glycated albumin Diabetes mellitus Diagnosis Sensitivity and Specificity Systematic review Metaanalysis Core Tip This is the first systematic review and metaanalysis investigating the utility of glycated albumin GA for the diagnosis of diabetes mellitus DM Three studies regarding gestational diabetes mellitus GDM were Objectives Guidelines recommend the diagnosis of diabetes should be based on either plasma glucose or glycated hemoglobin HbA 1C findingsHowever lately studies have advocated glycated albumin GA as a useful alternative to HbA 1cWe conducted a systematic review and metaanalysis to determine the overall diagnostic accuracy of GA for the diagnosis of diabetes Glycated albumin and diabetes mellitus PubMed Glycated albumin values of 165 and 178 are equivalent ie the same percentile as a FPG of 126 mgdL 699 mmolL and Hb A 1c of 65 in US adult without diagnosed diabetes Glycated albumin values were truncated at the 1st percentile in A and B for clarity All figures are presented on the log scale Studies have revealed that glycated albumin GA is a useful alternative to HbA 1c under conditions wherein the latter does not reflect glycaemic status accurately Until now there are few studies with nonAsians subjects that report on the validity of GA test in diagnosis of type 2 diabetes mellitus DM Thus the aim of this study was to Glycated albumin in diabetes mellitus a metaanalysis of PubMed Glycated albumin as a biomarker for diagnosis of diabetes mellitus A Intriguing data are emerging suggesting that glycated albumin may be a better test than HbA 1c for diabetes screening in nonobese patients Koga et al found a negative correlation between glycated albumin and BMI in Japanese individuals this finding has been replicated in other Asian populations 6263 Glycated albumin in diabetes mellitus dog diabetes life expectancy a metaanalysis of diagnostic
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