glycemic control and cardiovascular disease in diabetes type 2 - Conclusions Sodiumglucose cotransporter2 inhibitors and glucagonlike buah yang tidak boleh dikonsumsi untuk penderita diabetes peptide1 receptor agonists should be included in the therapeutic plan of patients with type 2 diabetes mellitus and overt cardiovascular disease with due attention paid to improvement of glycemic control which may amplify their benefit on MACE Cardiovascular disease is the major cause of morbidity and mortality in people with Type 2 diabetes and risk of atherosclerotic disease is markedly increased in people with diabetes compared to people with normal glucose tolerance The excess risk can not be completely explained by increased preval Cardiovascular disease in type 2 diabetes mellitus progress The clinical management of people with type 2 diabetes T2D has evolved substantially over the past decade There has been increasing attention to the management of cardiovascular disease CVD risk associated with T2D moving the focus beyond glycemic control to treatments buttressed by randomized clinical trial evidence robustly demonstrating the safety and efficacy of cardiometabolic Glycemic variability and cardiovascular disease in patients Investigators conducted a literature search of the MEDLINE database from January 1950 through April 2009 using the Medical Subject Headings cardiovascular diseases coronary disease stroke peripheral vascular diseases hypoglycemic agents and diabetes mellitus type 2 as well as the keywords coronary heart disease glucose control and Goff DC Jr Gerstein HC Ginsberg HN et al Prevention of cardiovascular disease in persons with type 2 diabetes mellitus current knowledge and rationale for the Action to Control Cardiovascular Risk in Diabetes ACCORD trial Am J Cardiol 2007994i20i doi 101016jamjcard200703002 Google Scholar For sodiumglucose cotransporter 2 SGLT2 blockers a similar situation pertains in that the only reported study BI 10773 Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients EMPAREG OUTCOME is in people with prior CVD and had an unusually high initial event rate The primary objective was a PDF Effect of poor glycemic control on the prevalence and The Diabetes Control and Complications Trial DCCT a prospective randomized controlled trial of intensive mean A1C about 7 53 mmolmol versus standard mean A1C about 9 75 mmolmol glycemic control in patients with type 1 diabetes showed definitively that better glycemic control is associated with 5076 reductions in rates of Cardiovascular Disease and Type 2 Diabetes Has the Dawn of a The prevention and control the type2 diabetes by changing Comprehensive Management of Cardiovascular Risk Factors for The Role of Alternative Medicine in Managing Type 2 Diabetes The relationship between glucose control and cardiovascular outcomes in type 2 diabetes has been a matter of controversy over the years Although epidemiological evidence exists in favor of an adverse role of poor glucose control on cardiovascular events intervention trials have been less conclusiv LowCarb and Ketogenic Diets in Type 1 and Type 2 Diabetes It is well known that the multiple factors contributing to the pathogenesis of type 2 diabetes T2D confer an increased risk of developing cardiovascular disease CVD Although the relationship between hyperglycemia and increased microvascular risk is well established the relative contribution of Lindeberg and associates reported a randomized controlled study in Diabetologia in 2007 in which a cohort of 29 patients with ischemic heart disease and either glucose intolerance or type 2 diabetes was placed on either a Paleolithic diet or a Mediterranean diet The Mediterranean diet was based on whole grains lowfat dairy products Cardiovascular disease and intensive glucose control in type As large randomized clinical trials RCTs and their followup extensions accrued experts have interpreted their results as confirming that tight glycemic control prevented microvascular complications of type 2 diabetes mellitus but they may only prevent cardiovascular complications and mortality in some patients perhaps those newly diagnosed with this condition 9 14 The body of The importance of intensive glycemic management for protection against microvascular and cardiovascular disease CVD in diabetes was established for type 1 diabetes in the Diabetes Control and Complications Trial DCCTEpidemiology of Diabetes Interventions and Complications EDIC study Although the benefit of glycemic management on Effects of Exercise on Glycemic Control and Body Mass in Type The increased risk of cardiovascular disease CVD in people with diabetes is well established 1 and is now estimated to be between 16 and 23fold 2 The availability of effective cholesterol and blood pressure treatments facilitated a shift in the management approach for type 2 diabetes T2D from the glucocentric focus of decades ago The occurrence and development of coronary heart disease CHD are closely linked to fluctuations in blood glucose levels While the efficacy of intensified treatment guided by HbA1c levels remains uncertain for individuals with diabetes and CHD this review summarizes the findings and conclusions regarding HbA1c in the context of CHD Our review showed a curvilinear correlation between Most observational studies have shown an association between glucose control and cardiovascular disease 36 clinical trials of glycemic control in type 2 diabetes 712 a clearer picture laporan kasus diabetes melitus However IF is certainly beneficial for fasting blood glucose control Insulin sensitization and improvement of insulin resistance are not only international research hotspots but also important strategies in the current treatment of type 2 diabetes and cardiovascular diseases 22 23 Central obesity and increased visceral fat mass are the First hyperglycemia is a weak risk factor for CV disease Intensive glycemic control failed to decrease CV events in the Action to Control Cardiovascular Risk in Diabetes ACCORD Action in Diabetes and Vascular Disease Preterax and Diamicron MR Controlled Evaluation ADVANCE and VADT studies in T2D patients with longstanding diabetes Glycemic management and vascular complications in type 2 Diabetes a chronic metabolic disorder marked by elevated blood glucose levels is increasingly prevalent globally significantly impacting healthrelated quality of life Type 2 diabetes T2DM characterized by insulin resistance and inadequate insulin production presents a substantial public health challenge necessitating comprehensive management strategies Conventional treatments 6 Glycemic Targets Standards of Medical Care in Diabetes Videos for Glycemic Control And Cardiovascular Disease In Diabetes Type 2 Followup of Glycemic Control and Cardiovascular Outcomes in The Beneficial Effects of a Paleolithic Diet on Type 2 Glycemic control and cardiovascular disease in type 2 Glycemic Control Preexisting Cardiovascular Disease and We recruited volunteers who had type 2 diabetes mellitus and a glycated hemoglobin level of 75 or more and who either were between the ages of 40 and 79 years and had cardiovascular disease or Sodiumglucose cotransporter 2 inhibitors and newonset Reconsidering the role of glycaemic control in cardiovascular Glucose Control and Vascular Outcomes in Type 2 Diabetes Is Intensified glycemic control by HbA1c for patients with Effect of Intermittent Fasting Diet on Glucose and Lipid Reconsidering the role of glycemic control on cardiovascular Cardiovascular disease and glycemic control in type 2 Highest dietary fiber consumers when compared to the lowest consumers had a 1530 decrease in allcause and cardiovascular mortality and incidence of coronary heart disease type 2 diabetes and colorectal cancer and incidence and mortality from stroke a significantly lower bodyweight systolic blood pressure and total cholesterol were Type 2 diabetes mellitus T2DM is associated with a high risk of complications essentially macrovascular events Surprisingly the effect of improved glucose control on coronary and cerebrovascular complications and the target level of glycated hemoglobin HbA1c in this population remains quest It has been estimated that the number of diabetes sufferers in the world will double from the current value of about 190 million to 325 million during the next 25 years123 Individuals with type2 diabetes are at a high risk of developing a range of debilitating complications such as cardiovascular disease peripheral vascular disease Cardiovascular diseases CVDs are the main cause of death among patients with type 2 diabetes mellitus T2DM particularly in low and middleincome countries To effectively prevent the development of CVDs in T2DM considerable effort has been made to explore novel preventive approaches individualized glycemic control and cardiovascular risk management strict blood pressure and lipid Effect of poor glycemic control on the prevalence and determinants of anemia and chronic kidney disease among type 2 diabetes mellitus patients in Jordan An observational crosssectional study Glycemic Control for Patients With Type 2 Diabetes Mellitus Betaglucans in the treatment of diabetes and associated Effects of Intensive Glucose Lowering in Type 2 Diabetes The aim of this metaanalysis was to determine the effect of sodiumglucose cotransporter 2 inhibitors SGLT2i on incident diabetes in HF across the spectrum of left ventricular ejection fraction LVEF and across the broader spectrum of cardiovascular or kidney disease Glucose Control and Cardiovascular Disease in Type2 Diabetes Glycated hemoglobin is currently the gold standard for assessment of longterm glycemic control and response to medical treatment in patients with diabetes Glycated hemoglobin however does not address fluctuations in blood glucose Glycemic variability GV refers to fluctuations in blood glucose levels Recent clinical data indicate that GV is associated with increased risk of hypoglycemia Cardiovascular disease remains the leading cause of death in patients with diabetes Cardiovascular disease in diabetes is multifactorial and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events The 2015 American Heart Association and American Diabetes Association scientific statement Update on Prevention of Cardiovascular Disease in Adults Glycemic Control Preexisting Cardiovascular Disease and Context Exercise is widely perceived to be beneficial for glycemic control and weight loss in patients with type 2 diabetes However clinical trials on the effects of exercise in patients with type 2 diabetes have had small sample sizes and conflicting resultsObjective To systematically review New Perspectives in Management of Cardiovascular Risk Among Intensive glucose control trials suggest that the 9 lower risk of MACE associated with intensive glycemic control as compared with conventional glycemic control is only driven by patients with type 2 diabetes mellitus without olahraga yang baik untuk penderita diabetes cardiovascular disease at baseline
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