how diabetes cause atherosclerosis - Atherosclerosis is the major macrovascular complications ikan gabus obat diabetes of diabetes and the primary underlying cause of cardiovascular disease CVD posing heavy burden on the health care system In this review we discuss the involvement of dyslipidemia in the progression of atherosclerosis by activating the proinflammatory cytokines and oxidative stress Atherosclerosis is one of the main complications of diabetes involving multiple causative factors Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated with both diabetes and atherosclerosis Although the pathological link between diabetes and atherosclerosis is wellestablished better comprehension of Clinical Update Cardiovascular Disease in Diabetes Mellitus Both type I and type II diabetes are powerful and independent risk factors for coronary artery disease CAD stroke and peripheral arterial disease Atherosclerosis accounts for virtually 80 of all deaths among diabetic patients Prolonged exposure to hyperglycemia is now recognized a major factor in the pathogenesis of atherosclerosis in diabetes Hyperglycemia induces a large number of Clinical relationships between diabetes and atherosclerosis are well established The majority of the clinical and experimental data regarding the onset of diabetes complications are associated with atherosclerosis suggesting that the impact of chronic hyperglycaemia might induce damage on vascular homeostasis mainly attributable to the endothelium function Diabetes and Vascular Disease Circulation AHAASA Journals Vascular diseases particularly atherosclerosis are major causes of disability and death in patients with diabetes mellitus Diabetes mellitus substantially increases the risk of developing coronary cerebrovascular and peripheral arterial disease The pathophysiology of vascular disease in diabetes involves abnormalities in endothelial A simplified scheme of the pathophysiological connection of diabetes mellitus and atherosclerosis Dyslipidemia hyperglycemia and insulin resistance result in a spectrum of physiological changes including apakah kekurangan cu dapat menyebabkan diabetes melitus the formation of atherogenic lowdensity lipoprotein LDL advanced glycation end products AGE and activation of proinflammatory signaling that impact different cell types of the How hyperglycemia promotes atherosclerosis molecular mechanisms Cardiovascular disease remains the principal cause of death and disability among patients with diabetes mellitus Diabetes mellitus exacerbates mechanisms underlying atherosclerosis and heart failure Unfortunately these mechanisms are not adequately modulated by therapeutic strategies focusing solely on optimal glycemic control with currently available drugs or approaches In the setting of Atherosclerosis accounts for virtually 80 of all diabetesrelated mortality It is also a principal reason for hospitalization of patients with diabetes Diabetes profoundly affects the pathogenesis of atherosclerosis through various mechanisms Established cardiovascular risk factors are more prevalent in diabetic than in nondiabetic patients Dyslipidemia Diabetes and Atherosclerosis Role of Inflammation and The Diabetes MellitusAtherosclerosis Connection The Role of Lipid and Atherosclerotic cardiovascular disease ASCVD is accelerated in people with diabetes Dyslipidemia hyperglycemia oxidative stress and inflammation play a role via a variety of mechanisms operative in the artery wall In addition some unique features predispose people with type 1 diabetes to accelerated atherosclerosis Various organizations have created guidelines that provide advice NLRP3 plays an important role in both diabetes and atherosclerosis While the diversity of its activation modes is one of the underlying causes of complex effects in the progression of diabetes and atherosclerosis it also provides many new insights for targeted interventions in metabolic diseases Diabetes and Atherosclerosis Mechanisms and Management The link between diabetes and atherosclerosis PubMed Diabetes Mellitus Promotes the Development of Atherosclerosis The Role The link between diabetes and atherosclerosis Lucia La Sala Lipidlowering in denver diabetes care diabetes An update Atherosclerosis
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