lipoatrophy diabetes - View of Insulin induced lipodystrophy British diabetes cards Journal of Diabetes Lipoatrophy in Children With Type 1 Diabetes PMC Lipoatrophic Diabetes Mellitus an overview ScienceDirect Lipoatrophic diabetes is a heterogeneous group of disorders characterized by complete or partial absence of adipose tissue associated with diabetes mellitus A primary cause has been identified in the form called familial partial lipoatrophy also known as Dunnigan syndrome This is a gene defect localized to chromosome 1q2122 and its Before the advent of recombinant human insulin insulininduced lipoatrophy was a common problem among insulin users Lipoatrophy is a clinical condition characterized by localized loss of subcutaneous fat The prevalence of lipoatrophy was reported to be as high as 2455 with animal insulins Fortunately Insulin induced lipoatrophy and more commonly lipohypertrophy are dermatological complications of insulin therapy Lipoatrophy is becoming less common with the advent of newer insulin analogues however lipohypertrophy is still prevalent Whilst an immunological mechanism is postulated for lipoatrophy direct local anabolic action of insulin is postulated for lipohypertrophy Lipoatrophic diabetes mellitus refers to a condition characterized by severe insulin resistance and metabolic disturbances caused by a lack of fat in the body It is associated with genetic syndromes such as familial partial lipoatrophy and BerardinelliSeip congenital lipodystrophy Human InsulinInduced Lipoatrophy Diabetes Care In most reported cases of insulininduced lipoatrophies there were attempts of changing the injection areas without any evidence of improvement 58Kumar et al in a singleblind study used small amounts of dexamethasone adding 4 μgunit to insulin injections in nine patients with marked lipoatrophy in both thighsA mix of insulin and dexamethasone was injected into one thigh and Longterm insulin use can be associated with local subcutaneous fat abnormalities obat herbal mata kabur akibat diabetes in patients with diabetes Local fat accumulation lipohypertrophy is still a frequent problem associated with long diabetes duration and nonrotation of the injection sites 1 Local fat loss lipoatrophy is clinically characterized by visible cutaneous depression and palpable atrophy of subcutaneous fat tissue Background Lipoatrophy LA a rare skin complication in patients with type 1 diabetes T1D has decreased dramatically over the past decades due to the use of human purified insulin preparations Methods We collected data from the records of T1D patients with LA Types of insulin and insulin regimen presence of eosinophilia antiinsulin IAA antiGAD antiIA2 autoantibodies other Lipoatrophy developed at age 162 86 years after insulin administration for 104 84 years Lipoatrophy was associated with continuous insulin infusion in three of the subjects Insulin analogs associated with lipoatrophy included aspart n 4 lispro n 4 NPH n 3 glargine n 1 and regular n 1 Lipoatrophy was seen Lipoatrophic Diabetes A Case Report with a Brief Review of the Concurrence of Lipoatrophy and Lipohypertrophy in Children With Type 1 Lipoatrophy a rare complication of diabetes a singlecenter Insulin induced lipodystrophy British Journal of Diabetes Lipoatrophic Diabetes Mellitus an overview ScienceDirect Lipoatrophic diabetes is a diagnosis given to patients who have diabetes mellitus in association with lipoatrophy It is an extremely rare condition with devastating consequences and until recently treatment options have been limited Insulin induced lipoatrophy and more commonly lipohypertrophy are dermatological complications of insulin therapy Lipoatrophy is becoming less common with the advent of newer insulin analogues however lipohypertrophy is still prevalent Whilst an immunological mechanism is postulated for lipoatrophy direct local anabolic action of insulin Human Insulin diabetes by marilyn johnson penerbit indonesia publishing house AnalogInduced Lipoatrophy Diabetes Care
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